• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 7, Issue 7
  3. Authors

Online ISSN: 2515-8260

Volume7, Issue7

In-silico directions on Anti-diabetic and pkSCM Predictions of Novel Guanidinopyrimidines

    Jayaraman Arikrishnan Mannathusamy Gopalakrishnan Srinivasan Pazhamalai Haridoss Manikandan Selvarasu Sekar Panneerselvam Kalaivani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6968-6985

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Novel 2-(3-(4-methyl / 4-chlorophenyl)guanidine-1-yl)-4,6-disubstituted phenyl pyrimidine (7) were synthesized by simple condensation between therapeutic chalcone with bioactive biguanide derivatives. It was established by different spectral studies. Furthermore, subject to ADMET prediction using pkSCM server and molecular docking studies against human glucokinase protein (PDB ID: 1V4S) plays an important role in the novel drug development of type 2 diabetes and the synthesized compounds results are compared with currently used FDA approved drug and also the theoretical calculations were performed by DFT method. To learn the compound reactivity; HOMO – LUMO energy-gap, MEP surface and some other properties of the compound 7a were investigated.
Keywords:
    pyrimidine Anti-diabetic ADMET-pkSCM Molecular docking DFT
  • PDF (567 K)
  • XML
(2021). In-silico directions on Anti-diabetic and pkSCM Predictions of Novel Guanidinopyrimidines. European Journal of Molecular & Clinical Medicine, 7(7), 6968-6985.
Jayaraman Arikrishnan; Mannathusamy Gopalakrishnan; Srinivasan Pazhamalai; Haridoss Manikandan; Selvarasu Sekar; Panneerselvam Kalaivani. "In-silico directions on Anti-diabetic and pkSCM Predictions of Novel Guanidinopyrimidines". European Journal of Molecular & Clinical Medicine, 7, 7, 2021, 6968-6985.
(2021). 'In-silico directions on Anti-diabetic and pkSCM Predictions of Novel Guanidinopyrimidines', European Journal of Molecular & Clinical Medicine, 7(7), pp. 6968-6985.
In-silico directions on Anti-diabetic and pkSCM Predictions of Novel Guanidinopyrimidines. European Journal of Molecular & Clinical Medicine, 2021; 7(7): 6968-6985.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 238
  • PDF Download: 363
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus