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Synthesis and characterization studies of novel ternary complexes of Zn(II) and Ni(II) ion with norfloxacin drugs and amino acids

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    • Damini Vishwakarma, Sanju Agrawal, Noorafsha, Anupama Kashyap, Anil Kumar Kashyap, Nitin A. Mirganec
,

Document Type : Research Article

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Abstract

In the present work, we have synthesized twenty (20) Zn(II) and Ni(II) ion ternary complex with fluoroquinolone drug (Norfloxacin (NOR)) as primary ligand and-proline, L-glycine, L-alanine, L-histidine, L-arginine, L-threonine, L-valine, L-methionine, L-tryptophan, L-lysine , L-leucine, L-tyrosine, L-cysteine amino acid (AA) as the secondary ligand. Initial characterization studies have been done by elemental analysis to get information on the percent composition of C, H, N, O, S elements and metal, while UV-Visible spectroscopy shows the effect of metal chelation on the different inter-ligand transitions. Magnetic moment confirms the diamagnetic and paramagnetic behaviour of Zn (II) complexes and Ni (II) because there are all paired and two unpaired electrons are present in the outer orbital of the central zinc and nickel metal ion respectively. So the Zn and Ni metal shows +2 oxidation state in all synthesized complexes. While IR studies confirm the presence of all functional groups in synthesized complexes. Synthesized new ternary complexes contains [Zn(II)(NOR)(AA)] and [Ni(II)(NOR)(AA)] is1:1:1 molar ratio.   The zinc and nickel ion in these 20complexes have similar coordination modes, which can be described as six coordinated octahedral geometry. Stability of the all  ternary complexes was determined by thermal gravimetric analysis (TGA) in temperature ranges between 25 -900 . The carboxylic and amino acid group participate in the bonding and the interaction of the metal ion with an amino acid.

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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 9
December 2020
Page 2181-2202
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APA

Nitin A. Mirganec, D. V. S. A. N. A. K. A. K. K. (2021). Synthesis and characterization studies of novel ternary complexes of Zn(II) and Ni(II) ion with norfloxacin drugs and amino acids. European Journal of Molecular & Clinical Medicine, 7(9), 2181-2202.

MLA

Damini Vishwakarma, Sanju Agrawal, Noorafsha, Anupama Kashyap, Anil Kumar Kashyap, Nitin A. Mirganec. "Synthesis and characterization studies of novel ternary complexes of Zn(II) and Ni(II) ion with norfloxacin drugs and amino acids". European Journal of Molecular & Clinical Medicine, 7, 9, 2021, 2181-2202.

HARVARD

Nitin A. Mirganec, D. V. S. A. N. A. K. A. K. K. (2021). 'Synthesis and characterization studies of novel ternary complexes of Zn(II) and Ni(II) ion with norfloxacin drugs and amino acids', European Journal of Molecular & Clinical Medicine, 7(9), pp. 2181-2202.

VANCOUVER

Nitin A. Mirganec, D. V. S. A. N. A. K. A. K. K. Synthesis and characterization studies of novel ternary complexes of Zn(II) and Ni(II) ion with norfloxacin drugs and amino acids. European Journal of Molecular & Clinical Medicine, 2021; 7(9): 2181-2202.

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