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Emerging Trends Of Liquid Crystalline Nanoparticles Drug Delivery For Pulmonary Disorders

    Authors

    • Vrinder Pal Singh
    • Meenu Mehta
    • Saurabh Satija
    • Deep Shikha Sharma
    • Pardeep Kumar Sharma

    School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab (India)–144411

,

Document Type : Research Article

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Abstract

In this era of nanotechnology lyotropic liquid crystalline nanoparticles (cubosomes) are relatively less explored lipid-based nanocarriers that can be formulated selectively and specificity for almost all administration routes. The natural compounds are proved to be significantly curative in pulmonary diseases due to reported anti-oxidant, anti-inflammatory and immunomodulatory activities. The natural products have limited bioavailability due to either hydrophilic or low water solubility. These limitations can be overcome by using a novel nanotechnology such as cubosomes or liquid crystalline nanoparticles (LCNs). LCNs can easily encapsulate both hydrophilic and hydrophobic compounds because of the amphiphilic nature of lipid monoolein (MO). LCN can be used to co-deliver synthetic and natural compounds irrespective of their solubility due to multi-compartment structure. We can use LCNs to formulate drugs of synthetic origin with natural one to overcome multidrug resistance (MDR).

Keywords

  • Cubosomes
  • liquid crystalline nanoparticles
  • monoolein
  • Pulmonary Diseases
  • multidrug resistance
  • lipid nanocarrier
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 7
November 2020
Page 2558-2564
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  • Article View: 230
  • PDF Download: 344

APA

Singh, V. P., Mehta, M., Satija, S., Sharma, D. S., & Sharma, P. K. (2020). Emerging Trends Of Liquid Crystalline Nanoparticles Drug Delivery For Pulmonary Disorders. European Journal of Molecular & Clinical Medicine, 7(7), 2558-2564.

MLA

Vrinder Pal Singh; Meenu Mehta; Saurabh Satija; Deep Shikha Sharma; Pardeep Kumar Sharma. "Emerging Trends Of Liquid Crystalline Nanoparticles Drug Delivery For Pulmonary Disorders". European Journal of Molecular & Clinical Medicine, 7, 7, 2020, 2558-2564.

HARVARD

Singh, V. P., Mehta, M., Satija, S., Sharma, D. S., Sharma, P. K. (2020). 'Emerging Trends Of Liquid Crystalline Nanoparticles Drug Delivery For Pulmonary Disorders', European Journal of Molecular & Clinical Medicine, 7(7), pp. 2558-2564.

VANCOUVER

Singh, V. P., Mehta, M., Satija, S., Sharma, D. S., Sharma, P. K. Emerging Trends Of Liquid Crystalline Nanoparticles Drug Delivery For Pulmonary Disorders. European Journal of Molecular & Clinical Medicine, 2020; 7(7): 2558-2564.

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