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  2. Volume 7, Issue 7
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Online ISSN: 2515-8260

Volume7, Issue7

Advanced Glycation End-Products In Diabetes Complications

    Anush N Bineesh C. P. Jeena Gupta Pranav Kumar Prabhakar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2190-2198

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Abstract

Diabetic complications, such as, retinopathy, nephropathy lead to blindness and end stage renal failure respectively, various neuropathies, and ultimately increased mortality. While the exact mechanisms that lie behind the pathological changes associated with diabetes remain obscure, however, it is widely believed that chronic or intermittent hyperglycemia may alter various metabolic pathways at the tissue level, for instance, increased flux through the polyol and the hexosamine pathways as well as a persistent activation of protein kinase C (PKC). Reducing sugars such as glucose and fructose may react non-enzymatically through their carbonyl groups with free amino groups of proteins (commonly the Ɛ amino group of lysine) to form a Schiff base intermediate which then rearranges to a more stable structure known as Amadori product. The Amadori products generated by the aforementioned Maillard reaction may then undergo further reactions, including dehydration, oxidation and rearrangement resulting in the irreversible formation of heterogeneous advanced glycation end products (AGEs)
Keywords:
    Diabetes protein kinase complications hyperglycemia Glucose hexosamine
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(2020). Advanced Glycation End-Products In Diabetes Complications. European Journal of Molecular & Clinical Medicine, 7(7), 2190-2198.
Anush N; Bineesh C. P.; Jeena Gupta; Pranav Kumar Prabhakar. "Advanced Glycation End-Products In Diabetes Complications". European Journal of Molecular & Clinical Medicine, 7, 7, 2020, 2190-2198.
(2020). 'Advanced Glycation End-Products In Diabetes Complications', European Journal of Molecular & Clinical Medicine, 7(7), pp. 2190-2198.
Advanced Glycation End-Products In Diabetes Complications. European Journal of Molecular & Clinical Medicine, 2020; 7(7): 2190-2198.
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