European Journal of Molecular & Clinical Medicine

Abstract

BACKGROUND: A major health problem is hypertension during pregnancy. This complicates In India, around 5 to 10 percent of pregnancies occur. Preeclampsia is a disorder whose pathogenesis is still not clearly understood. One theory suggested that the cause of PE is, endothelial dysfunction is brought about by certain factors released from ischemic placenta leading to poor uterine and placental perfusion. Preliminary executive research suggests that serum LDH and uric acid are abnormal in women with preeclampsia-eclampsia and usual in women with normotension. AIM AND OBJECTIVES: We aim to study the correlation between serum lactate dehydrogenase levels and serum uric acid levels in in normotensive pregnant women and preeclamptic-eclamptic pregnant women together with their feto-maternal performance. The objectives of the study to compare and correlate serum lactate dehydrogenase and serum uric acid levels in normotensive and preeclamptic-eclamptic women with feto-maternal outcome. MATERIALS AND METHODS: This is a prospective observational study and will be conducted in the obstetrics and gynaecology department, AVBRH, DMIMS (Deemed to be University, Wardha), situated in the rural area of Wardha district in over 230 patients for period between 2020-23. This study will include antenatal patients of age 18 - 35yrs, gestation 28-40 weeks, normotensive and preeclampsia-eclampsia women and will exclude mothers with hypertension < 20 weeks of gestation (Chronic Hypertension), multiple pregnancy, pre-existing Diabetes Mellitus, liver disorder, renal disorder, epileptic disorder, thyroid disorder, Heart Disease, leukaemia, haemolysis and hepatitis. EXPECTED RESULTS: We expect that there will be significant difference in maternal and fetal outcome based on serum lactate dehydrogenase and serum uric acid concentration in normotensive and preeclamptic -eclamptic pregnant women.