European Journal of Molecular & Clinical Medicine

Abstract

Calcifying odontogenic cyst (COC) is also known as “Gorlin cyst,” first described by Gorlin in 1962 which is a rare developmental odontogenic lesion. The calcifying odontogenic cyst (COC) is a heterogeneous lesion existing either as cystic or solid variant. This lesion has different terminologies and is classified into various subtypes. The World Health Organization classified (2005) COC as a neoplasm and used the term calcifying cystic odontogenic tumor for benign cystic type, the dentinogenic ghost cell tumor for the benign solid type lesions and the malignant type as ghost cell odontogenic carcinoma. The dentinogenic ghost-cell tumor (DGCT), a solid variant of the COC, is an uncommon odontogenic neoplasm. This article discusses the various terminologies, clinical features, classification, histopathology, and treatment of COC.