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An Insight Of DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors

    Author

    • Usha Subbiah, Debarshi Roy, Sonaa Elango

    Korea.

,

Document Type : Research Article

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Abstract

Background: Oral potentially malignant disorders (OPMD) of the oral mucosa are one of the increased risks of oral cancer transformation. This is primarily caused by habitual risk factors such as tobacco (smoking and smokeless), betel quid chewing and alcohol consumption, which are the most important etiologic factors. Multiple studies have assessed the correlation of increased oral cancer and oral potentially malignant disorder with polymorphism in DNA repair genes. Highlight: This review explores the genetic perspectives of the OPMD with special emphasis on DNA repair genes polymorphism associated with the risk exposures. The base Excision Repair (BER) pathway plays an important role in repairing damaged base pairs caused by oxidative stress due to tobacco carcinogens. Adenosine diphosphate ribosyl transferase (ADPRT), x-ray repair cross-complementing 1 (XRCC1), and apurinic/apyimidinic endonuclease (APE1), MGMT and other repair gene polymorphisms are involved with OPMD associated with habitual risk factors. Conclusion: Genetic differences between various ethnicities and differences in the carcinogenesis of OPMD development in various countries could partially explain the discrepant of these gene-environmental lifestyle habits. An understanding of DNA repair genetic variants associated with habitual risk factors contribute to more accurate identification and establishing tailor-made prevention measures.

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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 5
November 2020
Page 1340-1354
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  • Article View: 189
  • PDF Download: 277

APA

Sonaa Elango, U. S. D. R. (2020). An Insight Of DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors. European Journal of Molecular & Clinical Medicine, 7(5), 1340-1354.

MLA

Usha Subbiah, Debarshi Roy, Sonaa Elango. "An Insight Of DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors". European Journal of Molecular & Clinical Medicine, 7, 5, 2020, 1340-1354.

HARVARD

Sonaa Elango, U. S. D. R. (2020). 'An Insight Of DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors', European Journal of Molecular & Clinical Medicine, 7(5), pp. 1340-1354.

VANCOUVER

Sonaa Elango, U. S. D. R. An Insight Of DNA Repair Gene Polymorphism In Oral Premalignant Disorders Associated With Habitual Risk Factors. European Journal of Molecular & Clinical Medicine, 2020; 7(5): 1340-1354.

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