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Serum Neuron Specific Enolase (NSE) as a biomarker for Hypoxic Ischemic Encephalopathy in a tertiary care hospital- A prospective study

    Authors

    • Dr. Debajani Panda 1
    • Anup kumar Rana 2
    • Dr Bibhudatta Dash 3
    • Dr. Subhashree Ray 4
    • Dr. Rachita Sarangi 5

    1 P.G. Resident, Department of Pediatrics, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga nagar, Bhubaneswar- 751003, Odisha, India

    2 Assit.prof. ,Biochemistry , IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga nagar, Bhubaneswar- 751003, Odisha, India

    3 Assistant Professor, , Department of Pediatrics, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga nagar, Bhubaneswar- 751003, Odisha, India

    4 Professor-HOD Dept. Of Biochemistry, IMS and SUM Hospital, S’O’A University,Bhubaneswar

    5 Professor, , Department of Pediatrics, IMS & SUM Hospital, Siksha O Anusandhan University, K8, Kalinga nagar, Bhubaneswar- 751003, Odisha, India

,

Document Type : Research Article

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Abstract

Background: The cause for disease and mortality throughout the infant was hypoxic ischemical encephalopathy secondary to perinatal asphyxia. It leads to permanent neuropsychological disability. Identification of a biomarker for hypoxic insult can not only help in earlier implementation of neuro-protective strategies but also in prognosticating the long term outcome.
Method: A prospective observational study conducted in IMS and SUM hospital over a period of 2 years in which 60 newborns with clinical evidence of HIE were recruited as case group. A group of 20 newborns with no evidence of HIE served as control. The serum neuron specific enolase (NSE ) levels at 4hours and 48 hours of birth of both the groups were tested and compared.
Results: The mean serum NSE levels at 4hours and 48 hours was significantly higher in the case group ( 42.43 ng/ml, 28.97 ng/ml) as compared to the control group (18.51ng/ml, 15.62ng/ml). Additionally, the mean serum NSE stages increased by the harshness of HIE in the various subgroups as per the clinical staging. ROC curve for this study has shown a good predictability for neurological outcome. For the cut off value of 40.4 mcg/l, the sensitivity was 80 % and specificity was 81.2 %.
Conclusion: Serum NSE levels can be a reliable biomarker for neurological insult in Hypoxic ischemic Encephalopathy insult in order to implement early neuroprotective strategy

Keywords

  • Neuron precise enolase
  • Hypoxic ischemic encephalopathy
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 6
November 2020
Page 1230-1235
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  • Article View: 418
  • PDF Download: 311

APA

Panda, D. D., Rana, A. K., Dash, D. B., Ray, D. S., & Sarangi, D. R. (2020). Serum Neuron Specific Enolase (NSE) as a biomarker for Hypoxic Ischemic Encephalopathy in a tertiary care hospital- A prospective study. European Journal of Molecular & Clinical Medicine, 7(6), 1230-1235.

MLA

Dr. Debajani Panda; Anup kumar Rana; Dr Bibhudatta Dash; Dr. Subhashree Ray; Dr. Rachita Sarangi. "Serum Neuron Specific Enolase (NSE) as a biomarker for Hypoxic Ischemic Encephalopathy in a tertiary care hospital- A prospective study". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 1230-1235.

HARVARD

Panda, D. D., Rana, A. K., Dash, D. B., Ray, D. S., Sarangi, D. R. (2020). 'Serum Neuron Specific Enolase (NSE) as a biomarker for Hypoxic Ischemic Encephalopathy in a tertiary care hospital- A prospective study', European Journal of Molecular & Clinical Medicine, 7(6), pp. 1230-1235.

VANCOUVER

Panda, D. D., Rana, A. K., Dash, D. B., Ray, D. S., Sarangi, D. R. Serum Neuron Specific Enolase (NSE) as a biomarker for Hypoxic Ischemic Encephalopathy in a tertiary care hospital- A prospective study. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 1230-1235.

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