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Comparative Study Of Some Immunological Aspects Between Type I And Type II Diabetic Mellitus In Iraqi Patients Of Thi-Qar Province.

    Authors

    • Hayfaa A. Thijail BSc
    • Hind M. Mousa PhD

    College of Since , University of Thi-Qar

,

Document Type : Research Article

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Abstract

This study designed to compare the vital role of the inflammatory immune responses and autoimmunity in development both types of diabetic mellitus by measurement of serum IL-17 , and Anti-Gad levels among patients groups and healthy by using ELISA kits . The study included sixty DM patients were divided into two groups : 30 patients with Type I DM ( 33.7% ) , and 30 patients with Type II DM (33.7%) . In addition to 29 healthy individuals were (32.6 %) . The results indicated an elevated mean serum level of IL-17 and Anti-Gad in both patients groups , as compared with the healthy control with significant difference . Also, the findings recorded a highly significant difference in IL-17 and Anti-Gad sera levels between both types of patient groups at (P< 0. 01) . According to the correlation results between IL-17 and Anti-Gad in patients groups , the data was demonstrated that the expression of IL-17 had a significant positive correlation with expression of Anti-Gad (P< 0.05) among Type I patients . Whereas an inverse very weak correlation was observed between IL-17 and Anti-Gad with no significant (P ˃ 0.05) in Type 2 patients . we concluded the an elevated levels of IL-17A in both types of DM may be as a prognostic factor for development them in Iraqi population. We also conclude that elevated Anti-Gad in Type II DM may be an indication of the rapid development of undiagnosed insulin deficiency in latent autoimmune diabetes in adult patients .

Keywords

  • diabetes mellitus
  • IL-17
  • Anti-Gad-65
  • Auto-immune diseases
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 1
January 2020
Page 3537-3546
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APA

Thijail BSc, H. A., & Mousa PhD, H. M. (2020). Comparative Study Of Some Immunological Aspects Between Type I And Type II Diabetic Mellitus In Iraqi Patients Of Thi-Qar Province.. European Journal of Molecular & Clinical Medicine, 7(1), 3537-3546.

MLA

Hayfaa A. Thijail BSc; Hind M. Mousa PhD. "Comparative Study Of Some Immunological Aspects Between Type I And Type II Diabetic Mellitus In Iraqi Patients Of Thi-Qar Province.". European Journal of Molecular & Clinical Medicine, 7, 1, 2020, 3537-3546.

HARVARD

Thijail BSc, H. A., Mousa PhD, H. M. (2020). 'Comparative Study Of Some Immunological Aspects Between Type I And Type II Diabetic Mellitus In Iraqi Patients Of Thi-Qar Province.', European Journal of Molecular & Clinical Medicine, 7(1), pp. 3537-3546.

VANCOUVER

Thijail BSc, H. A., Mousa PhD, H. M. Comparative Study Of Some Immunological Aspects Between Type I And Type II Diabetic Mellitus In Iraqi Patients Of Thi-Qar Province.. European Journal of Molecular & Clinical Medicine, 2020; 7(1): 3537-3546.

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