• Register
  • Login

European Journal of Molecular & Clinical Medicine

  1. Home
  2. Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.

    Authors

    • RENUGADEVI KARTHIKEYAN 1
    • JULIUS AMALDAS 2

    1 Department of Biochemistry, Bharathiar University, Coimbatore - 641 046, Tamil Nadu, India

    2 Julius Amaldas Sree Balaji Dental College & Hospital, Chennai - 600 100, Tamilnadu, India

,

Document Type : Research Article

  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Aim of this study was to investigate the growth inhibitory effect of Artemesis annua L. silver nanoparticles (A.annua AgNPS) on human triple negative breast cancer tumor cell line MDA-MB-231. Cells were cultured and treated with A.annua water extract and A.annua AgNPS to determine the half inhibitory concentration (IC50). Oxidative stress was determined using lipid peroxidation (LPO), ROS generation and by determining the levels of antioxidants, superoxide dismutase (SOD) and reduced glutathione (GSH). Further, the mechanism of apoptotic induction was assessed by DNA fragmentation analyses. We observed that A.annua AgNPS significantly caused growth inhibition by increasing levels of LPO and ROS, in a dose dependent manner with reduced level of endogenous antioxidant enzymes. Increased shear in genomic DNA from MDA MB231 cells treated with A.annua AgNPS shows apoptosis to be the cause of cell cell death. We conclude that A.annua AgNPS can be useed as a therapeutic agent against breast cancer.

Keywords

  • Artemesia annua· Silver nanoparticle· Breast cancer· Apoptosis
  • XML
  • PDF 402.51 K
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
    • Article View: 278
    • PDF Download: 330
European Journal of Molecular & Clinical Medicine
Volume 7, Issue 3
November 2020
Page 1686-1697
Files
  • XML
  • PDF 402.51 K
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 278
  • PDF Download: 330

APA

KARTHIKEYAN, R., & AMALDAS, J. (2020). Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.. European Journal of Molecular & Clinical Medicine, 7(3), 1686-1697.

MLA

RENUGADEVI KARTHIKEYAN; JULIUS AMALDAS. "Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.". European Journal of Molecular & Clinical Medicine, 7, 3, 2020, 1686-1697.

HARVARD

KARTHIKEYAN, R., AMALDAS, J. (2020). 'Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.', European Journal of Molecular & Clinical Medicine, 7(3), pp. 1686-1697.

VANCOUVER

KARTHIKEYAN, R., AMALDAS, J. Artemisia annua L. silver nanoparticles exhibit anticancer activity by ROS mediated apoptosis in MDA-MB-231 cells.. European Journal of Molecular & Clinical Medicine, 2020; 7(3): 1686-1697.

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus