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  2. Volume 7, Issue 3
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Online ISSN: 2515-8260

Volume7, Issue3

Profile of Vitamin D and Interleukin-8 in COPD Exacerbation

    Riswan Idris Muhammad Ilyas Erwin Arief Syakib Bakri A Makbul Aman Haerani Ra-syid Hasyim Kasim Andi Fachruddin Benyamin Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1484-1494

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Abstract

Background: To determine the profile of vitamin D and interleukin-8 (IL-8) in COPD exacerbation.
Method: This research is an analytical study with a cross-sectional approach conducted at the Wahidin Sudirohusodo Hospital Makassar from March-June 2020. Serum levels of vitamin D (25-hydroxyvitamin D) and IL-8 were measured using the ELISA method in 65 exacerbated COPD patients based on clinical examination, chest radiograph, & spirome-try. The exacerbation criteria were based on Anthonisen and divided into two groups ac-cording to the exacerbation frequency in the past year (frequent exacerbations was often ≥ 3 times/year, infrequent exacerbation < 3 times/year) and related to gender, age, nutrition-al status, smoking status based on the Brinkman index, and obstruction degree according to the Global Initiative for Obstructive Lung Disease (GOLD) 2019.
Results: This study consisted of 65 exacerbated COPD subjects (62 men, 95.4%), with age of ≥ 60 years 73.8%, frequent exacerbations of ≥ 3 times/year, 69.3%, vitamin D deficiency status of 76.9 %, and it was found to be significantly lower (15.1 ng/ml) at the frequent ex-acerbations of ≥ 3 times/year (P <0.01). The means of IL-8 levels were 187.48 +68.30 ng/L and found to be significantly higher (206.7 ng/L) in the frequent exacerbations ≥ 3 times/year (P <0.01). In all subgroups according to gender, age, nutritional status, smok-ing status, and obstruction degree, there was a tendency for the lowest vitamin D and higher IL-8 in the frequent exacerbations of ≥3times/year. Conclusion: Vitamin D levels were found to be the lowest and IL-8 was higher in COPD patients with frequent exacerbations of ≥ 3 times/year, compared to those with the infre-quent exacerbations of < 3 times/year.
Keywords:
    COPD exacerbation Vitamin D Interleukin-8
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(2020). Profile of Vitamin D and Interleukin-8 in COPD Exacerbation. European Journal of Molecular & Clinical Medicine, 7(3), 1484-1494.
Riswan Idris; Muhammad Ilyas; Erwin Arief; Syakib Bakri; A Makbul Aman; Haerani Ra-syid; Hasyim Kasim; Andi Fachruddin Benyamin; Arifin Seweng. "Profile of Vitamin D and Interleukin-8 in COPD Exacerbation". European Journal of Molecular & Clinical Medicine, 7, 3, 2020, 1484-1494.
(2020). 'Profile of Vitamin D and Interleukin-8 in COPD Exacerbation', European Journal of Molecular & Clinical Medicine, 7(3), pp. 1484-1494.
Profile of Vitamin D and Interleukin-8 in COPD Exacerbation. European Journal of Molecular & Clinical Medicine, 2020; 7(3): 1484-1494.
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