European Journal of Molecular & Clinical Medicine

Abstract

Gallstones represent a significant public health problem in
modern societies, affecting 10% to 15% of the adult population. The types of gallstones
include mixed, cholesterol and pigment stones. This study was aimed to evaluate the serum
lipid profile and common bile duct diameter in patients with gallstones pre-operatively and
post operatively and to establish the effect of cholecystectomy on lipid profile and common
bile duct dimensions.
Materials and Methods: The study was conducted in Narayana Medical College and
Hospital, Nellore, Andhra Pradesh, India. This was a prospective observational study carried
out from August 2019 to March 2020.
Results: Out of total 50 cases, 29 cases (58%) were female and remaining 21cases (42%)
were male.Highest number of cases were in the age group 30-40 years (38%) followed by
30% between 40 to 50 years of age.In the present study, there was decrease in Total
Cholesterol levels, Low density lipoprotein (LDL) and Very low density lipoprotein (VLDL)
levels 1 week after surgery, 1 and 3 months after surgery. Triglycerides (TG) levels initially
increased after 1 week and decreased significantly 1 and 3 months after surgery. Significant
increase in HDL levels are seen after 1week which continued till 3months after surgery.
The current study showed an significant increase in CBD diameter of 0.53, 0.76 and 1.07 mm
in 1week, 1month and 3 months respectively after surgery.
Conclusion: It can be concluded from this study that cholecystectomy results in
normalization of lipid levels.And also increases the diameter of Common bile duct but within
physiological limits of that age and sex group