European Journal of Molecular & Clinical Medicine

Abstract

Etomidate is a rapidly acting induction agent and it has little effect on cardiovascular system and it allows rapid recovery from anaesthesia but associated with side effects. Pre-treatment with narcotic analgesics usually Fentanyl can decrease the incidence of pain on injection and myoclonus during induction of anaesthesia with Etomidate and also attenuates the stress response to endotracheal intubation.
OBJECTIVE: The objective was to find an optimal pre induction dose of &many with etomidate as induction agent which attenuates the haemodynamic changes and side-effects during induction and intuhatidn.
METHODS AND METHODS: Patients scheduled for elective surgeries under general anaesthesia were eligible for the study. 30 Patients were randomly assigned to two groups according to the pretreatment dose of Fnetanyl.
1)      Group I received 2 µg/kg of  Fentanyl
2)      Group II received 5 µg/kg of Fentanyl
         After 5 minutes of administration of either one of these all patients where induced with  Etomidate at a dose of 0.3 mg/kg.
RESULTS: We found that the hemodynamic response and side effects were lower in group II with increasing dose of Fentanyl. But at the same time there was increasing incidence of post operative nausea & vomiting and apnoea in group II.
CONCLUSION: We concluded that at a dose of 5 µg/kg of fentanyl, there is reduction of side effects of etomidate and also there is attenuation of hemodynamic response to intubation in patients undergoing elective surgeries under general anaesthesia with etomidate as induction agent.