European Journal of Molecular & Clinical Medicine

Abstract

Background: Patients with diabetes mellitus (DM), have  poor long term glycaemic control,  even when fasting glucose concentrations are normal.^{3, 4}, Glycosylated haemoglobin (HbA1c) is a useful index of glucose intolerance and hyperglycaemia.HbA1cis an established marker of long-term glycaemic control. HbA1c can be assessed in the non-fasted state and has higher reproducibility than fasting glucose
Aim of the study : To study the blood levels of HbA1C in patients of Acute Coronary Syndrome at the time of admission and to find out the correlation with the angiographic pattern.
Materials and methods :Cross sectional study was conducted in the Department of general medicine, at Sundaram Arulrhaj Hospitals Tuticorin, Tamil Nadu in Patients with a confirmed diagnosis of Acute Coronary Syndrome .
Reslts : Among the people with SVD,18 (100%) participants had<6.5% HbA1c, 27 (56.25%) participants had 6.5-8.5 HbA1c and 8 (36.36%) participants had 8.5 – 10.5 HbA1c. Among the people with DVD,16 (33.33%) participants had 6.5-8.5 HbA1c, 10 (45.45%) participants had 8.5 – 10.5 HbA1c and 3 (25%) participants had >10.5 HbA1c. Among the people with TVD,5 (10.41%) participants had 6.5-8.5 HbA1c, 4 (18.18%) participants had been with 8.5 – 10.5 HbA1c and 9 (75%) participants had>10.5 HbA1c
 
Conclusion : Our data suggest that HbA1c level is a significant and independent maker for the severity of angiographic lesion in ACS patients, irrespective of other cardiovascular risk factors, age, and gender, smoking, alcoholism. HbA1c values can be a predictor of the prevalence of complex coronary artery lesions.  It may be used as a cardiac marker in risk stratification of the patients presenting with acute coronary syndrome and indicated for coronary angiography.HbA1c levels are also to be included in investigations apart from routine Blood sugar  levels  in Out Patient Clinics and adoption of lifestyle changes & medications are to be taken to prevent the cardiovascular complications and morbidity from Diabetes mellitus.