Abstract

In this present investigation piperine loaded nanogel for skin cancer was formulated by using piperine, carbopol, sodium tripolyphosphate
Method
Piperine loaded Nanogel is formulated by Ion gelation method using stpp, chitosan and it is evaluated by Entrapment efficiency, particle size analyzer, zeta potential,  effect of particle size,  Fourier- transformed infrared spectroscopy, screening electron microscopy, ex Vivo permeation study, box behnken design, regression analysis, formulation of nanoparticles, incorporation into transdermal nanogel and evaluated by physical examination drug content, extrudability, spreadibility, in Vivo study, washablity, stability study of gel, in Vivo dissolution, drug diffusion study
Result
Stiring time, sodium sulfate concentration, stiring speed, effect influence the particle size and instrument efficiency formulation percentage drug release particle size in a range of 0 to 200 NM where obtained data potential is 3.2 mv which can show good storage time for nanoparticles approx 10 months poly dispersity index was 0.152 which is below 1 was acceptable range Entrapment efficiency was 95% training electron microscopy show spherical shape of nanoparticles obtained Nanogel so 87% of drug release no skin irritation for physical examination  consistency, wash ability, spread ability, drug content, stability study, in vitro drug release, in Vivo drug release, ex Vivo drug release where in acceptable range
Conclusion
Clear nanogel is obtained by physical examination for topical drug delivery system and drug bioavailability enhanced for 30% in market it was enhanced up to 85% current work can be useful for successful preparation and evaluation of Nanogel for treatment of skin cancer