Study of serum LDH levels and its correlation with maternal and perinatal outcome in preeclampsia
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 12203-12208
AbstractBackground: Pre-eclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Lactate dehydrogenase (LDH) is an intracellular enzyme which converts pyruvic acid to lactic acid during glycolysis Present study was aimed to study the correlation of maternal and perinatal outcomes with serum LDH levels in women with hypertensive disorders of pregnancy.
Material and Methods: Present study was prospective, observational study, conducted in antenatal women with singleton pregnancy and gestational age 28 weeks onward with hypertensive disorders of pregnancy (mild/ severe pre-eclampsia), serum LDH levels were estimated.
Results: In present study, 50 pregnant women were studied. Majority women were from 20-25 years age group (60 %), nulliparous (70 %), unbooked (68 %). Hypertensive disorders of pregnancy were mild pre-eclampsia (56 %) & severe pre-eclampsia (44 %). In present study, Mean LDH value in mild preeclampsia group was 564.3 ± 184.3 IU/l & in severe preeclampsia group was 766.3 ± 264.3 IU/l, difference was statistically significant. Majority women underwent LSCS (64 %). Maternal complications such as eclampsia, abruption, HELLP were more in > 800 IU/L LDH value patients. Perinatal outcome was poor in pregnant women with > 800 IU/L LDH value, 8 (16 %) neonates required NICU admission, while 7 (14 %) were low birth weight. Perinatal mortality was noted in 2 cases (1 from 600-800 IU/L LDH group & 1 from >800 IU/L LDH group).
Conclusion: With raised LDH values, decision regarding management and prevention of complications should be taken, so as to reduce the maternal & neonatal, morbidity & mortality.
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