European Journal of Molecular & Clinical Medicine

Abstract

Aim: To evaluate Lipid profile of pregnant women during all the three trimesters of pregnancy.
Materials and Methods: This prospective observational cross sectional study was conducted in the Department of Obstetrics and Gynaecology, Rajindra Hospital, Patiala in 1000 women attending antenatal clinic and labor room. Their lipid profile was done and proportion of dyslipidemia during pregnancy was recorded. Samples from all subjects were collected under aseptic precaution; 5 ml of non-fasting venous blood was collected in plain vacutainer from antecubital vein. After the clot retracts the sample was centrifuged at 4000 rpm for 5 min the serum separated and stored at 4°C pending assay for lipid profile. Serum TGs, TC, and HDL cholesterol was analyzed by enzymatic methods with the help of Glaxo kits on ERBA Chem-5 plus semi-auto analyzer in the department of biochemistry, GMC, Rajindra hospital Patiala.
Results:  Out of 1000 patients, 5.6% patients were from <20 years age groups, 31.6% patients were from 20-25 years age groups, 35.7% patients were from 25-30 years age group, 20.9% patients were from 30-35 years age group and 6.2% patients were from >35 years age group. 20.5% patients came from rural area and 79.5% from urban area. The mean cholesterol levels in first second and third trimester were 187.86 mg/dl, 252.36 mg/dl and 294.43 mg/dl respectively showing significant rise in levels of TC with subsequent trimester. The mean TG levels in one, second and third trimester were 142.2 mg/dl, 252.33 mg/dl and 309.97 mg/dl respectively showing a significant rise in levels with subsequent trimester. The mean HDL levels in one, second and third trimester were 53.78 mg/dl, 57.12 mg/dl and 54.07 mg/dl respectively. Levels rise in 2nd trimester and there is significant fall in values between 2nd and 3rd trimester. The mean LDL levels in one, second and third trimester were 105.6 mg/dl, 144.8 mg/dl and 178.4 mg/dl respectively. Values increases with subsequent trimesters. The mean VLDL levels in one, second and third trimester were 28.4 mg/dl, 48.5 mg/dl and 57.6 mg/dl respectively showing significant rise in levels with subsequent trimester. The mean TG/HDL ratio in one, second and third trimester was 0.16 mg/dl, 0.68 mg/dl and 1.73 mg/dl respectively.
Conclusion: After three months of pregnancy, there was a substantial increase in total cholesterol, triglyceride level, HDL, LDL, VLDL and TG/HDL ratio in the serum. Values of HDL rises in 2nd trimester and there is seen a decline in 3rd trimester.