STUDY OF RENAL FUNCTION IN PATIENTS WITH HYPOTHYROIDISM ATTENDING A TERTIARY CARE HOSPITAL
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 1, Pages 1634-1639
AbstractBackground:Thyroid function has been suggested to have a relationship with kidney function and chronic kidney disease. Present study was aimed to study renal function tests in patients with hypothyroidism attending a tertiary care hospital.
Materials and Methods: Present study was hospital based, case-control study, conducted in Cases (Patients 21-60 years, of either sex, newly diagnosed cases of hypothyroidism, attending the medicine outpatient department, willing to participate) & controls (healthy age-matched subjects).
Results: In present study 100 cases & 100 case-controlled matches were studied. Age, gender & BMI were comparable among cases & controls, difference was not statistically significant. Among cases 26 had overt hypothyroidism & 74 had subclinical hypothyroidism. We compared T3, T4, TSH, Urea and Creatinine values among cases & controls. TSH and Creatinine levels were more among cases as compared to controls & difference was statistically significant. While T3, T4 & Urea levels were comparable among cases & controls, difference was not statistically significant. Pearson correlation was significant for values between TSH and serum creatinine while correlation between TSH and serum urea was not significant.
Conclusion: Subclinical hypothyroid state is associated with a consistent elevation in the serum creatinine levels due to a decrease in the GFR.
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