European Journal of Molecular & Clinical Medicine

Abstract

Thyroid hormone abnormality is mutual in foremost psychiatric disorders. Thyroid hormones play critical function in the method of Neurogenesis and Neurodevelopment i.e., Myelination, dendrite proliferation and formation of synapses. There is link among thyroid axis and several experienced psychiatric disorders. Noteworthy results on cerebral thyroid characteristic are observed while there are even small variations in thyroid hormone levels, within the normal range. Alterations in mood, behaviour and cognition are resulting from this. Depression, psychosis and cognitive disorder are observed in the patients of hypothyroidism. Meanwhile, people with hyperthyroidism had been observed to have psychosis, aggression, anxiety as well as cognitive impairment. Memory impairment is related with Subclinical hypothyroidism.
The objective of this study was to analyse the socio-demographic profile with assessment and comparison the type of thyroid dysfunction among patients with major psychiatric disorders. This was a cross-Sectional Observational study on 166 patient samples. Assess serum thyroid stimulating hormone (TSH), T3 (triiodothyroxine), T4 (L-thyroxine), free unbound fractions of T3 and T4 (FT3 and FT4) with the COBAS e 411 ANALYSER at Kalpana path lab, R.M.R.S.M.B. govt. hospital, Udaipur for all recruited patients.
Result of our study is that thyroid dysfunction occurs significantly in patients with psychiatric disorders. Subclinical hypothyroidism was the most common abnormality observed in the study population. Thyroid dysfunctions were predominant in females. Most of the cases with thyroid dysfunction were from rural area and age group 41-50 years. In present study, 25% of total cases drug naïve for ≥ 6 months and 10.6% of total new cases had thyroid dysfunction. Most of the cases with thyroid dysfunction were related to F20-F29 block. Isolated increased FT4 level found in significant proportion of population. This is a useful finding as this calls for frequent monitoring of Thyroid function tests in all psychiatric patients on treatment, to enable proper management.