European Journal of Molecular & Clinical Medicine

Abstract

Background: The interpeduncular angle in the brain is defined as the angle formed by the medial margins of the posterior half of the cerebral peduncles on axial MRI brain images. Our study was aimed to assess the normal interpeduncular angle, ponto-mamillary distance and maximum AP and lateral diameters of the brain across various age groups in the Indian population & to establish reference values for the same which may aid in clinical diagnosis.
Material and Methods: The study was a single-center, retrospective, observational study. The brain MRI studies for patients with non-specific complaints over a 6 month period were included in the study.
Results: 400 cases (50 cases were included per decade from 10 to 90 years age groups) were studied. The maximum lateral dimensions of the brain appear to slightly decrease with each decade of life as expected however the maximum AP diameter was relatively constant. The ponto-mamillary distance showed no specific trend and remained relatively constant across all the age groups. The inter-observer variation was good for the interpeduncular angle, pontomamillary distance, maximum lateral and AP diameters of the brain.
Conclusion: The interpeduncular angle was found to slightly increase with each decade of life. The maximum lateral dimensions of the brain appear to slightly decrease with each decade of life as expected however the maximum AP diameter was relatively constant.