European Journal of Molecular & Clinical Medicine

Abstract

Background: Pathophysiologically, vitamin D deficiency has been related to inflammation
and immune dysfunction, which may be the potential reason for the increased susceptibility
of the individual to severe infection or sepsis. The present study was conducted to analyze the
association between serum vitamin D concentration and mortality in severe septic patients.
Materials and Methods: Whole blood collected was placed into the tubes containing
ethylenediaminetetraacetic acid as an anticoagulant. After completion of samples, the
concentration of serum 25-hydroxy vitamin D3 was measured by enzyme-linked
immunosorbent assay (ELISA). SPSS version 20.0 (IBM Corp., Armonk, NY, USA) was
used for data analysis. P-values less than 0.05 were considered statistically significant.
Results: In the present study a total of 250 patients were included in which 110(44%) were
females and 140(56%) were males. The prevalence of vitamin D insufficiency in critically ill
subjects with sepsis was 100% (250/250). 32% patients with non-severe sepsis,16% with
severe sepsis, and 48% with septic shock. Patients suffering from severe septic had lower
levels of vitamin D compared to those with septic shock and non-severe sepsis. 12.5%
patients with severe sepsis who had vit D3 deficiency died and 50% patients with septic
shock who had vit D3 deficiency died.
Conclusion: 12.5% patients with severe sepsis who had vit D3 deficiency died and 50%
patients with septic shock who had vit D3 deficiency died.