European Journal of Molecular & Clinical Medicine

Abstract

Introduction: QT interval abnormalities are the best predictors of cardiovascular deaths .Microalbuminuria is an independent marker for cardiovascular disease in diabetes mellitus. Hence QT interval abnormalities in diabetics with or without microalbuminuria were evaluated in this study.
Material and Methods: This study done in the Dept. of  General Medicine at Dr. N. D. Desai Faculty of Medical Science & Research, Nadiad, and  NAMO Medical college and research centre from( May 2021 to Dec 2021). Open label controlled study with 214 subjects of either sex. Group A healthy subjects (n=100), group B asymptomatic, type 2 diabetics with no clinical evidence of cardiac disease. Group B subdivided into B1 with microalbuminuria (n=62), B2 without microalbuminuria (n=52). Corrected QT interval (QTC), microalbuminuria, and blood pressure were measured for all subjects. QTC was calculated by using Bazzet's formula .QTC more than 440msec was considered prolonged.
Results: QTC was within normal range in diabetic patients(415+25msec). Highly significant (p<0.0001) prolongation was observed in diabetics, compared to healthy subjects. Both B1 (p<0.0001) and B2 (p<0.001) groups showed a significant increase in QTC than in healthy subjects. Among B1 and B2 groups QTC was not statistically significant.
Conclusion: QTC was more in asymptomatic type 2 diabetics irrespective of microalbuminuria compared to healthy individuals, though values were within normal range.This denotes high risk for future cardiovascular complications in diabetic patients.