European Journal of Molecular & Clinical Medicine

Abstract

Homocysteine occupies a branch point in methionine, cysteine and S-adenosylmethionine (SAM) metabolism. About half of the homocysteine formed is conserved by remethylation to methionine in the “methionine cycle”. The other half is irreversibly converted by cystathionine-β-synthase (CBS) and cystathionine 𝛾-lyase to cysteine. After getting the informed consents from the subjects, 2.5ml of fasting blood samples were collected for lipid profile in a plain vacutainer tube and 2.5 ml of blood sample were collected in EDTA tubes for homocysteine estimation. This however, was done after the 7th day of the last menstrual period for premenopausal group. Samples were centrifuged at 3000 rpm to separate serum and plasma for the analysis of lipid profile and homocysteine estimation. The positive correlation between BMI and homocysteine which clearly indicates the increase in BMI results in increase in plasma homocysteine levels with Pearson correlation co-efficient of 0.232 and p value of 0.11.