European Journal of Molecular & Clinical Medicine

Abstract

Background: Using continuous glucose monitoring, compare glycemic variability (GV) indices between patients with fibrocalculous pancreatic diabetes (FCPD) and type 2 diabetes mellitus (T2D) (CGM).
Methods: We calculated GV indices in 61 patients with FCPD and T2D who were matched for HbA1c and diabetes duration. The CGM-derived measures of GV (SD, mean amplitude of glycemic excursion [MAGE], continuous overall net glycemic action [CONGA], absolute means of daily differences [MODD], M value, and coefficient of variance [percent CV]) and hypoglycemia (time spent below 70mg/dL, AUC below 70mg/dL, glycemic risk assessment diabetes equation hypoglycemia, Low Blood Glucose Index), and hyperglycemia (time spent above 180mg/dL at night [TSA > 180], AUC above 180mg/dL [AUC > 180], glycemic risk assessment diabetes equation hyperglycemia, High Blood Glucose Index [HBGI], and J index).The relationship between GV indices and HbA1c, diabetes duration, and demographic and biochemical data was also investigated.
Results: Except for M value, all of the CGM-derived GV parameters (SD, MAGE, CONGA, MODD, and percent CV) were substantially greater in the FCPD group than in the T2D group (P<0.05). The FCPD group had significantly greater levels of hyperglycemia (TSA >180, AUC >180, HBGI, and J index) than the T2D group (P<0.05). The levels of hypoglycemia in the two groups were not significantly different. In both groups, all hyperglycemia markers had a favourable connection with HbA1c.
Conclusions: T2D is linked to lower GV, whereas FCPD is linked to higher GV. Higher postprandial glycemic excursions were discovered in patients with FCPD, which could have treatment implications.