Abstract

Background: Bone marrow examination is an important tool in diagnosing and
controlling hematological disorders. Bone marrow aspiration and trephine biopsy are
compatible. Thus; compiled the current study to evaluate and compare the effectiveness
of bone marrow aspiration, imprint and biopsy in patients with acute leukemia.
Materials& Methods: The present study was conducted in 50 clinically suspected
patients of leukemia who attended inpatient and outpatient department of medicine,
department of general pathology at SMS Medical College and Hospital, Jaipur,
Rajasthan, India over a period of one year. All Patients with leukemia who underwent
both bone marrow aspiration and bone marrow trephine biopsy examination were
included in the present study. We analyzed all the results by SPSS software. One way
ANOVA was used for assessment of level of significance. P- value of less than 0.05 was
taken as significant.
Results: The age of the patients ranged from 6 months to 70 years with male to female
ratio of 1.5:1. In three cases, dry tap was observed, which was further diagnosed with
BMI and BMBx. Diluted marrow was observed in two cases which was further
diagnosed with BMI and BMBx. Findings of BMI and BMBx were in concordance with
each other in 100 percent of the cases.
Conclusion: Bone marrow aspiration, imprint and biopsy are complementary to each
other with aspiration smears being primarily used for cytological diagnosis and biopsy
sections mainly useful to identify histological features like architectural pattern and
fibrosis.