• Register
  • Login

European Journal of Molecular & Clinical Medicine

  1. Home
  2. Study of Thyroid Functions in Chronic Kidney Disease Patients

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

Study of Thyroid Functions in Chronic Kidney Disease Patients

    Author

    • Anvesh Kumar A, Kunche Sruthi, Megha Reddy
,

Document Type : Research Article

  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Background: Abnormal thyroid function tests are frequently observed in patients of
chronic kidney disease. Kidneys plays a significant role in thyroid hormone metabolism
by conversion of T4 to T3 (the active metabolite). Low plasma free T3 in ESRD is a
marker of the inflammation and endothelial activation; and is known to predict all
cause mortality. The present study was done look for the biochemical abnormalities of
thyroid function tests in chronic kidney disease and to correlate the severity of CKD
and alterations of thyroid indices.
Materials and Methods: In a cross sectional study, thyroid function test [TT3, TT4,
FT4, TSH] were estimated by CLIA in 50 patients of chronic kidney disease who were
in various stages. Symptoms of hypothyroidism, thyroid hormone abnormalities and
CKD stage were analyzed using Chi square test and ANOVA tests.
Results: Among the mean age was 48.8 ± 12.2 years of which 33 were male and 17
females. The mean value of TT3 in CKD stage 3, 4, 5 were 1.01±0.39; 1.05± 0.6;
0.95±1.09 μg/mL respectively. (p= 0.02 Significant). The mean value of TT4 in CKD
stage 3, 4, 5 were 6.3± 2.4; 5.5± 1.5; 5.11 ± 1.01 μIU/ml respectively. (p=0.71 Not
significant).
Conclusion: Total T3 and total T4 were found to be progressively decreased as stage of
CKD increased. There was no significant correlation between TT4 and CKD stage.
There was a significant correlation between the prevalence of thyroid dysfunction and
the stage of chronic kidney disease.Higher the degree of renal insufficiency, the higher
was the prevalence of thyroid hormone abnormalities, the levels of thyroid profile i.e
T3, T4 decreases and TSH increases as severity of renal failure increases. Thyroid
hormone abnormalities could represent a risk factor for cardiovascular disease and
might also be implicated in kidney disease progression.

Keywords

  • Chronic kidney disease
  • Thyroid Function Test
  • hypothyroidism
  • Subclinical hypothyroidism
  • XML
  • PDF 224.15 K
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
    • Article View: 135
    • PDF Download: 295
European Journal of Molecular & Clinical Medicine
Volume 9, Issue 3
February 2022
Page 1164-1174
Files
  • XML
  • PDF 224.15 K
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 135
  • PDF Download: 295

APA

Reddy, A. K. A. K. S. M. (2022). Study of Thyroid Functions in Chronic Kidney Disease Patients. European Journal of Molecular & Clinical Medicine, 9(3), 1164-1174.

MLA

Anvesh Kumar A, Kunche Sruthi, Megha Reddy. "Study of Thyroid Functions in Chronic Kidney Disease Patients". European Journal of Molecular & Clinical Medicine, 9, 3, 2022, 1164-1174.

HARVARD

Reddy, A. K. A. K. S. M. (2022). 'Study of Thyroid Functions in Chronic Kidney Disease Patients', European Journal of Molecular & Clinical Medicine, 9(3), pp. 1164-1174.

VANCOUVER

Reddy, A. K. A. K. S. M. Study of Thyroid Functions in Chronic Kidney Disease Patients. European Journal of Molecular & Clinical Medicine, 2022; 9(3): 1164-1174.

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus