European Journal of Molecular & Clinical Medicine

Abstract

Background: The prevalence of renal dysfunction has been reported to vary from 14-50% in
patients with cirrhosis. The prevalence is estimated to be approximately 50% among patients
with cirrhosis and ascites and 20% of patients with advanced cirrhosis admitted to the hospital
3,4. The wide range in prevalence is likely due to different study populations and varying
definitions of renal dysfunction. Patients with HRS who fail to respond to medical therapy or
those with severe renal failure of other etiology may require renal replacement therapy.
Simultaneous liver kidney transplant (SLK) is needed in many of these patients to improve
their post-transplant outcomes. However, the criteria to select patients who would benefit from
SLK transplantation are based on consensus and lack strong evidence to support them. Heath
care system has evolved over the last decade and newer drugs are available for the management
of complication of cirrhosis. We attempt to study its impact on course and outcome of acute
kidney injury. Also few of the patients could possibly be on the antiviral drugs for hepatitis B
and hepatitis C. If these patients are admitted they will be included in study and we would study
the effect of the effect of this drug on acute kidney injury and vice versa. Hence, the present
study was conducted to study clinical profile of patients with acute kidney injury in liver
cirrhosis.