Vitamin D status and its association with disease activity in early rheumatoid arthritis in rural population of central India
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 1, Pages 648-652
AbstractBackground: Rheumatoid arthritis (RA) is a chronic inflammatory disease
characterized by joint swelling, joint tenderness, and destruction of synovial joints,
leading to severe disability and premature mortality. Early rheumatoid arthritis is
defines as “RA with duration of disease/symptoms of disease < 6 month.”
Aim:To study serum vitamin D level in newly onset rheumatoid arthritis patients.
Methodology: It is a Case-control study, all patients fulfilling revised American College
ofRheumatology criteria/EULAR criteria(2010) for Rheumatoid Arthritis being
attended to in therheumatology clinic, Tools like Oral questionnaire, History &
Clinicalexamination,laboratory equipments will be used.Sample size is 45 cases and 45
controls, complying with inclusion and exclusion criteria.
Result: The study suggested that, mean value of Clinical Disease Activity Index (CDAI)
of RA was 12.24±8.05 in cases and 2.89±0.83 in control, DAS28 Score was 4.24 ± 1.07 in
cases and 3.00 ± 0.37 in control, it showed statistically significant association between
serum Vitamin D3 level with CDAI and DAS28 Score in rheumatoid arthritis patients.
Conclusion: The study results suggest that the inverse relationship between serum
Vitamin D levels and RA disease activity.
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