European Journal of Molecular & Clinical Medicine

Abstract

Aim: To investigate the relation of vitamin D concentration and parathyroid hormone with
insulin resistance in PCOS women.
Methods: In the department of Obstetrics and Gynecology at Dr. Baba Saheb Ambedkar
Medical College & Hospital, Rohini, Delhi, a one-year observational study was conducted.
The levels of 25, hydroxyvitamin D and PTH, as well as the levels of fasting sugar and
insulin in the blood, were tested.
Results: There was a 91.0 percent prevalence of vitamin D insufficiency (<20 ng/ml) in the
study, whereas 67.9 percent of participants had an elevated parathyroid hormone level.
According to the study, vitamin D insufficiency (r=-0.64, p=0.01) had a significant negative
connection with the HOMA-IR. Increased PTH levels were shown to have a positive
correlation with HOMA-IR.
Conclusion: Women with PCOS who have high parathyroid hormone levels or vitamin D
insufficiency have a higher incidence of glucose intolerance.
If vitamin D insufficiency and insulin resistance are strongly linked, it may be possible to
treat insulin resistance by raising vitamin D levels.