THE EFFECT OF 3 REGIMENS (0.3MG VS0.5MG VS 1MG.I.M.) OF VITAMIN K1PROPHYLAXIS AT BIRTH ON VITAMIN K STATUS IN PRETERM AND/OR VLBW INFANTS
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 4, Pages 1978-1985
AbstractVitamin K deficiency of the newborn has the potential risk of Vitamin K deficiency-related bleeding (VKDB) between birth and up to six months.Vitamin K deficiency may cause unexpected bleeding during the first week of life in previously healthy appearing neonates (early vitamin K deficiency bleeding [VKDB] of the newborn. Sequentially Numbered, Opaque Sealed Envelopes (SNOSE) method as described by Doig, G.S et al. has been used for allocation concealment in the study. The allocated intervention sequence was kept in individual, serially numbered sealed opaque covers and was kept under the custody of a senior faculty of the department but not involved in the study or patient care. The proportion neonates, who had Necrotizing Enterocolitis (NEC) (≥ Stage 3 by Modified Bell staging) was 4.2%, 11.5% and 8.0% in intervention group A, B and C respectively. The difference in this proportion was statistically not significant (P value 0.631). The proportion neonates, who had pulmonary hemorrhage was 0.0%, 7.7% and 4.0% in intervention group A, B and C respectively. The difference in these proportion was statistically not significant (P value 0.382).
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