European Journal of Molecular & Clinical Medicine

Abstract

Aim: To find the level of uric acid in patients of chronic liver disease and its correlation, if any, with etiology
and other parameters.
Materials and Method: This was a prospective study conducted on North Indian population admitted in
Department of Medicine during the period of 2020 and 2021. A total number of 50 patients diagnosed with
chronic liver disease were included in this study. A detailed history was elicited from the patients regarding
their present complaints; associated symptoms; alcohol intake, smoking, previous history of hypertension,
diabetes mellitus, arthritis, hypothyroidism, any cardiac illnesses and chronic drug intake. All patients
underwent an ultrasonogram abdomen and estimation of serum uric acid levels. Waist circumference in males
and females was measured. Glycemic and Body mass index were recorded. Serum uric acid level was sent for
analysis on the day of admission and was followed up.
Results: Out of 50 subjects, 38 (76%) were males and 12 (24%) were females. Mean ± SD uric acid (mg/dl)
among the study subjects was 6.69±2.92. Normal uric acid (3.1-5) was revealed among 24% of the subjects
while higher uric acid/hyperuricemia was reported among 38 (76%) subjects. Mean uric acid was 4.03, 5.17
and 8.94 among the subjects having CTP class A, B and C respectively. Pearson correlation analysis revealed
significant positive correlation between uric acid and total bilirubin, SGOT, SGPT and CTP Score.
Conclusion: Elevated serum uric acid level might be a risk factor for the incidence of chronic liver disease.
Hyperuricemia may act as a surrogate marker for assessing the prognosis of CLD.