Non synonymous A803G Polymorphism of N-acetyltransferase 2 Gene and Impaired lipid profile in Egyptian Obese Children and Adolescents
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 4, Pages 997-1006
Abstract: Childhood overweight and obesity remains an important public health concern. The prevlance of obesity and overweight among children and adolescents aged 5-19 years has risen dramatically from 4% to over 20%. The aim of the present study was to assess A803G polymorphism in the NAT2 gene in Egyptian obese children and adolescents and to detect the relation between this gene mutation and impaired lipid profile in them. Patients and methods: this cross sectional study included 100 obese children and adolescents divided into two groups according to their HbA1c results : group 1(pre-diabetic obese children and adolescents) and group 2 (Non- diabetic obese children and adolescents) , both groups are compatible as regard age and sex and had equal numbers (50). Whole blood samples were collected and underwent genotyping todetect NAT2 A803G gene polymorphism using Taqman allelic discrimination assay. Results: There was highly statistically significant higher total cholesterol, triglycerides and LDL among Group 1 than Group 2. But regarding HDL, it was highly statistically significant higher among Group 2 than Group 1. Heterozygous A allele of Group 1 group had the worst lipid profile characteristics (higher cholesterol, triglycerides and LDL and lower HDL) but this difference was statistically significant only regarding LDL while regarding otherpararmeters, they were not statistically significant. While, heterozygous G allele of Group 2 had the worst lipid profile characteristics (higher cholesterol, triglycerides and LDL and lower HDL) but this difference was statistically significant only regarding LDL while regarding other parameters, they were not statistically significant. Conclusion: Our study concluded that Egyptian obese children and adolescents who carrying the NAT2 A803 allele might be at a high risk of impaired lipid profile and consequent increased future risk to develop secondary metabolic diseases.
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