Abstract

Background: Allergic rhinitis (AR) is one of the most globally commondiseases and
usually persists throughout life. First-line drugs can be successfully used to control
AR. However, once these medications are terminated, the majority of AR patients
will reappear the symptoms of AR within a brief period. Thus, these medications do
not appear to exert a long-term effect on the baseline Total Nasal Symptom
Score.To study the relationship between the gut microbiota types and allergic
rhinitis. Patients and Methods: This case control study was carried out on 52
school-aged patients presented at Oto-rhino-laryngology, Head and Neck (ORLHNS)
Department and Microbiology and Immunology department at Zagazig
University. The patients were classified into 2 groups: Allergic rhinitis group: 26
individuals with allergic rhinitis Control group: 26 individuals without allergic
rhinitis. All patients in this study were subjected to the personal history taking,
physical examination and laboratory investigations including: eosinophilic count,
skin prick tests (SPT) for common perennial and seasonal allergens, measurement
of (total Ig E) and identifing bacteria (lactobacillus and bacteroides) by SYBR
Green real time PCR. Results: Age was distributed as 11.19±3.26 and 11.65±3.24
respectively between case and control with no significant difference between
groups. Mean disease duration was 6.15±2.01, the majority were Intermittent and
mild regard classification also the majority were trigger by inhalation. Skin prick
test among cases group showed majority were house dust and date palm pollens.
Absolute eosinophils counting was significantly higher among cases compared to
control one. Cases were significantly higher regard IgE distribution. Lactic acid
bacteria RNA was significantly higher among control group compared to cases
group while Bacteroid bacteria RNA was significantly higher among cases group
compared to control group. Conclusion: Lactic acid bacteria in gut microbiota of
school-aged individuals may influence sensitization to different allergens.