Assessment the level of Immunity against COVID-19 among Uttar
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 2, Pages 2721-2726
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS CoV 2) is the virus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the COVID-19 pandemic. It has created a devastating effect on humanity with social and economic depression. Europe and America were the hardest hit continents. India has also lost lives, making the country fourth most deadly worldwide. However, the infection and death rate per million and the case fatality ratio in Uttar Pradesh were substantially lower than in many States in India. Several factors have been proposed including genetics. One of the important facts is that a large chunk of Uttar Pradesh population is asymptomatic to the SARS-CoV-2 infection. Thus, the real infection in Uttar Pradesh is much higher than the reported number of cases. Therefore, the majority of people are already immune in the states. To understand the dynamics of real infection as well as the level of immunity against SARS-CoV-2, we have performed antibody testing (serosurveillance) in the urban region of ten districts in Uttar Pradesh in our survey, the prevalence frequency varied between 0.01-0.48, suggesting high variability of viral transmission between District. We also found out that the cases reported by the government were several folds lower than the real incidence of infection. This discrepancy is mainly driven by the higher number of asymptomatic cases. Overall, we suggest that with the high level of immunity developed against SARS-CoV-2 in the majority of the districts, the case fatality rate of second wave in India will be minor than first wave.
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