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  2. THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS

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THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS

    Authors

    • Abdulrhman M. Hassan Hadi 1
    • Ahmed Abdul-Hassan Abbas 2
    • Ahmed Sahib Abdulamir 2
    • Basman Medhat Fadheel 3

    1 Assistant Lecturer, M.Sc., College of Medical Analysis Techniques, Al-Bayan University

    2 Professor, Ph.D., Department of Microbiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq

    3 Assistant Professor, FIBMS, Department of Internal Medicine, College of Medicine, University of Baghdad

,

Document Type : Research Article

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Abstract

Background: Psoriasis is a chronic inflammatory skin disease has a strong genetic predisposition. Aim of the work: To study the role of TNFAIP3 rs610604 (C/A) polymorphism in psoriasis, and its effect on Etanercept response. Subjects and methods: One hundred patients with psoriasis, in addition 100 apparently healthy individuals as a control group were included in this study. Restriction Fragment Length Polymorphism-Polymerase Chain Reaction (RFLP-PCR) was performed to evaluate different TNFAIP3 gene polymorphism. TNFAIP3 serum levels were assessed by enzyme-linked immunosorbent assay. Results: Current study showed low serum level of TNFAIP3 protein in psoriatic patients when compared with control group (P<0.01). A considerably higher risk of psoriasis was observed in individuals who had TNFAIP3 rs610604 SNP CC and C allele than people carrying AA genotype and A allele. In relation to the response to treatment, this study observed that the mutant homozygous genotype CC was more frequent in non -responder (71.4%) than responder (1.3%) patients (P<0.01). Conclusion: TNFAIP3 rs610604 (C/A), might be useful for prognosis of psoriatic patients

Keywords

  • psoriasis
  • TNFAIP3 gene and Etanercept
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 9
December 2020
Page 240-246
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APA

Hassan Hadi, A. M., Abbas, A. A., Abdulamir, A. S., & Fadheel, B. M. (2020). THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS. European Journal of Molecular & Clinical Medicine, 7(9), 240-246.

MLA

Abdulrhman M. Hassan Hadi; Ahmed Abdul-Hassan Abbas; Ahmed Sahib Abdulamir; Basman Medhat Fadheel. "THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS". European Journal of Molecular & Clinical Medicine, 7, 9, 2020, 240-246.

HARVARD

Hassan Hadi, A. M., Abbas, A. A., Abdulamir, A. S., Fadheel, B. M. (2020). 'THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS', European Journal of Molecular & Clinical Medicine, 7(9), pp. 240-246.

VANCOUVER

Hassan Hadi, A. M., Abbas, A. A., Abdulamir, A. S., Fadheel, B. M. THE EFFECT OF TNFAIP3 GENE POLYMORPHISM on DISEASE SUSCEPTIBILITY AND RESPONSE of ETANERCEPT in PSORIATIC PATIENTS. European Journal of Molecular & Clinical Medicine, 2020; 7(9): 240-246.

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