Evaluation Of Safety And Efficacy Of Vitamin D Supplementation Inerectile Dysfunction Patients With Vitamin D Deficiency
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 4, Pages 225-230
AbstractAim: To evaluate the safety and efficacy of Vitamin D supplementation in erectile dysfunction patients with Vitamin D deficiency.
Material and Method: This study was carried out in Department of Urology, S.M.S. Medical College and attached Hospitals between March 2018 to April 2019 among patients in the age group 20-60 years presenting with ED and having severe Vitamin D deficiency. Patients were randomized into three groups. First group was treated with Tadalafil 10mg once a day while the second group had Tadalafil 10mg once a day plus Vitamin D 60,000 IU once a week, and third group was given Vitamin D 60,000 IU once a week only. Efficacy of drugs was evaluated at base line and after 12 weeks on the basis of International Index of Erectile Function Questionnaire scoring.
Results: After 12 weeks of treatment IIEF-5 scoring was nearly same as that of the base line with no significant difference in group C patients. On the other hand, IIEF-5 scoring was significantly improved in group A and B patients (P<0.001). On comparing group A and B patients there was significant improvement in group B compared to group A (P < 0.05). In comparison to group C, group A and group B patients had more side effects (P<0.05), but of mild intensity and prescribed medications were well tolerated. Group A and B patients had no significant difference in side effects.
Conclusion: This study showed that the use of Tadalafil in combination with Vitamin D in Vit D deficient ED patients act better than Tadalafil or Vit. D alone.
Keyword: ED, Vitamin D, Tadalafil, IIEF
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