• Register
  • Login

European Journal of Molecular & Clinical Medicine

  1. Home
  2. The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

    Authors

    • Mamareli V
    • Tanis O
    • Anastassopoulou J
    • Kyriakidou M
    • Mamareli CH
    • Koui M
    • Theophanides T
    • Mamarelis I
,

Document Type : Research Article

  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

There are many clinical evidences that hyperuricemia is a risk factor for the development of peripheral carotid and coronary vascular diseases. However, the mechanism of elevated uric acid concentration in biological systems is not yet clear. In the present work Fourier transform infrared (FT-IR) spectroscopy was used to evaluate the mechanism of calcification and plaque formation in carotid arteries in hyperuricaemic patients. Comparison between the spectra of carotid arteries from patients with elevated uric acid values and spectra obtained from patients with normal uric acid values showed structural changes of the characteristic spectral bands in the region 4000-500 cm-1. These changes were related with changes in the concentration of the serum uric acid and the clinical history of the patients. The intensity decrease of the infrared bands in the region 1650-1500 cm-1 was associated with the decrease of the apolipoprotein ratio, ApoI/ApoII, which corresponds to HDL (High Density Lipoproteins) and the regulation of the LDL (Low Density Lipoproteins), which are related to oxidation stress. The infrared band at 1467 cm-1 indicated the presence of urea components as a result of the metabolic pathway. The shape and the intensity of the bands between 1250-900 cm-1 depend on the glycation-end products of the diseases. SEM-EDX chemical analysis showed fibril formation and molybdenum release in hyperuricaemic patients.

Keywords

  • infrared spectroscopy
  • Oxidative Stress
  • molybdenum enzymes
  • hyperuricemia uric acid
  • SEM
  • EDEX
  • XML
  • PDF 1.72 M
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
    • Article View: 274
    • PDF Download: 293
European Journal of Molecular & Clinical Medicine
Volume 6, Issue 1
January 2019
Page 20-25
Files
  • XML
  • PDF 1.72 M
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 274
  • PDF Download: 293

APA

V, M., O, T., J, A., M, K., CH, M., M, K., T, T., & I, M. (2019). The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study. European Journal of Molecular & Clinical Medicine, 6(1), 20-25.

MLA

Mamareli V; Tanis O; Anastassopoulou J; Kyriakidou M; Mamareli CH; Koui M; Theophanides T; Mamarelis I. "The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study". European Journal of Molecular & Clinical Medicine, 6, 1, 2019, 20-25.

HARVARD

V, M., O, T., J, A., M, K., CH, M., M, K., T, T., I, M. (2019). 'The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study', European Journal of Molecular & Clinical Medicine, 6(1), pp. 20-25.

VANCOUVER

V, M., O, T., J, A., M, K., CH, M., M, K., T, T., I, M. The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study. European Journal of Molecular & Clinical Medicine, 2019; 6(1): 20-25.

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus