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The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro

    Authors

    • Quan Minh To 1
    • Dieu Quang Tran 1
    • Tuyet Thi Vy Le 1
    • Ha Le Bao Tran 1
    • Long Thanh Le 2

    1 University of Science, Vietnam National University of Ho Chi Minh city, Hochiminh city, Vietnam

    2 Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam

,

Document Type : Research Article

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Abstract

This study aimed to determine the ability of astaxanthin-rich Haematococcus pluvialis algal extract (AE) on preventing adverse effects of H2O2 on human skin fibroblast cells. A Haematococcus pluvialis strain obtained from Vietnam was used as a source of astaxanthin. hF cells were cultured in DMEM/F12 medium supplemented with AE 0, 10, 25, 50 μg/ml for 7 days. WST-1 assay results showed that AE 10-50 μg/ml was not poisonous and didn’t have any negative effects on cell proliferation. hF cells were pre-treated with AE (0, 10, 25, 50 μg/ml) for 24 hours prior to H2O2 treatment (200 μM, 120 minutes). The results showed that AE protected hF cells: reduction of G0/G1 phase cells in cell populations (16.08 – 21.52%), senescence-associated β-galactosidase – positive cells (28.9 – 40.8%), and maintenance of cell proliferation, nuclear area. AE 10 μg/ml is the optimal concentration in this study. In conclusion, AE has been shown to have the ability to protect fibroblasts from the adverse effects of H2O2.

Keywords

  • Astaxanthin
  • Haematococcus pluvialis
  • cell senescence
  • skin aging
  • hydrogen peroxide
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European Journal of Molecular & Clinical Medicine
Volume 8, Issue 3
February 2021
Page 1809-1819
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  • Article View: 473
  • PDF Download: 478

APA

To, Q. M., Tran, D. Q., Le, T. T. V., Tran, H. L. B., & Le, L. T. (2021). The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro. European Journal of Molecular & Clinical Medicine, 8(3), 1809-1819.

MLA

Quan Minh To; Dieu Quang Tran; Tuyet Thi Vy Le; Ha Le Bao Tran; Long Thanh Le. "The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro". European Journal of Molecular & Clinical Medicine, 8, 3, 2021, 1809-1819.

HARVARD

To, Q. M., Tran, D. Q., Le, T. T. V., Tran, H. L. B., Le, L. T. (2021). 'The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro', European Journal of Molecular & Clinical Medicine, 8(3), pp. 1809-1819.

VANCOUVER

To, Q. M., Tran, D. Q., Le, T. T. V., Tran, H. L. B., Le, L. T. The ability of astaxanthin-rich Haematococcus pluvialis algal extract on preventing harmful effects of H2O2 on human fibroblast cells in vitro. European Journal of Molecular & Clinical Medicine, 2021; 8(3): 1809-1819.

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