PSYCHIATRIC COMPLICATIONS IN PATIENTS RECEIVING CYCLOSERINE IN THE REGIMEN FOR MULTI-DRUG-RESISTANT TUBERCULOSIS

Abstract: Cycloserine is a second-line antitubercular drug used in the management of tuberculosis, particularly in cases where standard first-line therapies prove ineffective. Because its effectiveness against bacteria is well known, cycloserine is commonly linked to several mental health disorders. The review looks at how cycloserine affects the mental state of those taking it, paying special attention to anxiety, depression, difficulty sleeping, changes in mood, psychosis, and thoughts of suicide. Scientists analyze scientific papers, collective research, and case studies from everywhere to understand how often these reactions occur, how severe they can be, and what kinds of results they result in. Especially careful monitoring is given to elderly patients and patients dealing with viral diseases or other mental health conditions. The authors discuss potential biological reasons for cycloserine toxicity, including its effect on brain receptors related to mood and behavior and its role in increasing levels of oxidative stress. Since most drugs can cross the blood–brain barrier, side effects are more likely to occur. Tuberculosis care faces a significant safety concern because psychiatric screening is not done all the time. It suggests that mental health should be looked after now, help from specialists is needed, and the way patients are managed ought to be improved. Properly dealing with these neuropsychiatric issues helps provide top-quality, reliable, and safe treatment for those affected by multidrug-resistant tuberculosis.