ISSN 2515-8260
 

Review Article 


Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication

P Scalia, SJ Williams, R Luca’, Antonio Giordano, E Bucci.

Abstract
The agent of Covid19, Sars-CoV-2 has caused thousands of fatalities worldwide and overshadowed the number of deaths of other previous coronavirus
outbreaks (Sars-CoV1 2002 and MERS-CoV 2012). Although the new coronavirus pathogenicity is actively under investigation, part of its infectious
behavior can be linked to its higher binding affinity to the angiotensin-converting enzyme 2 (ACE2) in the respiratory tracts. However, the expression
of ACE2 per se may not be sufficient to justify the individual variability observed among affected patients in terms of clinical outcome in apparently
non-immune depressed, non-elders subjects. The present update provides an overview of the most recent scientific findings related to genetic
factors involved in the Sars-CoV-2 infectious process and their potential role in affecting the virus pathogenicity. The present update can provide valuable hints towards developing a predictive screening/susceptibility profile testing on individuals not yet infected and/or in non symptomatic positive subjects towards managing the current morbidity and mortality risk and establishing personalized intervention protocols for the early treatment of the Sars-CoV-2-associated life-threatening pulmonary complication.

Key words: Coronavirus, lung failure


 
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How to Cite this Article
Pubmed Style

Scalia P, Williams S, Luca' R, Giordano A, Bucci E. Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. EJMCM. 2020; 7(1): 05-09.


Web Style

Scalia P, Williams S, Luca' R, Giordano A, Bucci E. Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. http://www.ejmcm.com/?mno=116023 [Access: September 14, 2020].


AMA (American Medical Association) Style

Scalia P, Williams S, Luca' R, Giordano A, Bucci E. Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. EJMCM. 2020; 7(1): 05-09.



Vancouver/ICMJE Style

Scalia P, Williams S, Luca' R, Giordano A, Bucci E. Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. EJMCM. (2020), [cited September 14, 2020]; 7(1): 05-09.



Harvard Style

Scalia, P., Williams, . S., Luca', . R., Giordano, . A. & Bucci, . E. (2020) Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. EJMCM, 7 (1), 05-09.



Turabian Style

Scalia, P, SJ Williams, R Luca', Antonio Giordano, and E Bucci. 2020. Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. European Journal of Molecular & Clinical Medicine, 7 (1), 05-09.



Chicago Style

Scalia, P, SJ Williams, R Luca', Antonio Giordano, and E Bucci. "Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication." European Journal of Molecular & Clinical Medicine 7 (2020), 05-09.



MLA (The Modern Language Association) Style

Scalia, P, SJ Williams, R Luca', Antonio Giordano, and E Bucci. "Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication." European Journal of Molecular & Clinical Medicine 7.1 (2020), 05-09. Print.



APA (American Psychological Association) Style

Scalia, P., Williams, . S., Luca', . R., Giordano, . A. & Bucci, . E. (2020) Genetic and Cell biology Discriminants of Sars-CoV2 Infection and Susceptibility to Covid-19 pulmonary complication. European Journal of Molecular & Clinical Medicine, 7 (1), 05-09.





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