Online ISSN: 2515-8260

Keywords : Creatinine

A study on clinical profile in correlation with laboratory investigations and radiological findings in dengue fever

Dr. Abhishek Mahankali V; Dr. Mohtashim Jameel; Dr. Pallati Vijay Ananth

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1750-1756

Background and Objectives: To study the clinical manifestation, laboratory and radiological findings pertaining to Dengue fever. To obtain the sociodemographic profile of patients. To evaluate the clinical features observed in dengue patients. To carry of comparative study of clinical features with the laboratory and radiological findings in dengue patients

A Comparative Study of Serum Creatinine, Serum Uric Acid and Blood Urea in Normal Pregnant and Pregnancy Induced Hypertensive Subject

Bonala Sharat Babu, Azmatulla Shaik, Naveed Altaf, Md. Siddique Ahmed Khan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1280-1285

Background: Standard assessment of renal function in pregnancy is by measurement of
serum creatinine concentration yet normal gestational ranges have not been established.
The aim of this systematic review was to define the difference in serum creatinine in a
healthy pregnancy compared with concentrations in non-pregnant women to facilitate
identification of abnormal kidney function in pregnancy.
Materials and Methods: The study was performed on 70 pregnant women. Out of which
35 women were pregnancy induced hypertensive and 35 were normal pregnant women.
Results: The result showed significantly high blood pressure (SBP-197.21±21.7 VS
187.28±8.69, DBP 124.36±9.41 VS 99.2±6.28) and Blood urea (42.31 ±7.81 mg% VS
41.30±9.29 mg%), serum creatinine (3.45 ±1.19 mg% VS 3.18±1.38 mg%), serum uric
acid level (9.89±3.16 mg% VS 7.34±0.9 mg%) in pregnancy induced hypertensive
women compares to normal pregnant women. In the present study, in pre-eclampsia,
there is elevation of serum uric acid and serum creatinine elevated values are
statistically significant.
Conclusion: There is a renal derangement of parameters in preeclampsia so it may be
advised to renal function test to confirm involvement of renal dysfunctions.
Measurement of renal function Test could be used as a biochemical indicator in
pregnancy induced hypertensive women.

Serum Iron Profile in Non-Dialysis Chronic Kidney Disease Patients with Anemia

Sawjib Borphukan, Mohit Goyal, Girindra Nath Gogoi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1293-1302

Background: The present study aimed to evaluate the levels of serum iron, total iron
binding capacity (TIBC), transferrin saturation and serum ferritin in diagnosed cases of
chronic kidney disease due to any aetiology not undergoing dialysis. Study also aimed to
determine the correlation between serum creatinine and serum iron levels in chronic
kidney disease in this group of patients.
Materials and Methods: The present study was conducted in the city of Dibrugarh and
which also included patients belonging to adjoining districts of Upper Assam from 20th
October 2018 to 19th October 2019 for a period of 1 year. A clinico-hematological study
was undertaken to evaluate the levels of serum iron, total iron binding capacity (TIBC),
transferrin saturation and serum ferritin in diagnosed cases of chronic kidney disease
(not on dialysis) due to any aetiology. Study included 110 old and newly diagnosed cases
of CKD attending the out–patient department not on dialysis. A cut-off off Hemoglobin
<13 g/dl in men and <12 g/dl in women was used to make the diagnosis of anemia.
Results: Prevalence of anemia among CKD cases was observed as 74.6% with Hb level
<6 gm% was observed in 6.4% cases. Normocytic normochromic picture was observed
in 53.6% cases. Decreased level of serum iron, ferritin, TIBC and transferrin saturation
was seen in 99.1%, 16.4%, 52.75 and 78.2% cases respectively. Mean levels of
haemoglobin, RBC and iron indices (except for TIBC levels) decreased significantly
with increase in the CKD stage. A significant positive correlation was observed between
eGFR levels with haemoglobin and iron indices (except TIBC) while an inverse
correlation was observed with creatinine levels.
Conclusion: Anemia among Pre dialysis-CKD cases is mostly normocytic and moderate
in severity. Functional iron deficiency was the predominant form of iron deficiency in
these patients. Both hemoglobin and other iron indices worsens with progressive loss of
kidney functions.

Study and Comparison of Renal Function tests in Pre-eclampsia and Eclampsia with Normal Healthy Pregnant Women

Brungi Asha Jyothi, Madupathi Anil Babu, P.Vineela

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11693-11699

Background:Preeclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. It rarely presents before 20 weeks of gestation like in hydatidformmole.Eclampsia is a syndrome with one or more episodes of convulsions in association with preeclampsia .In India, the national incidence of hypertensive disorders   is 15.2%,with incidence in nulliparous women being four times greater than in multipara.With severe renal involvement, glomerular filtration may be impaired and the plasma creatinine concentration may begin to  rise.Elevated uric acid is another component of the preeclampsia. Although hyperuricemia does correlate with maternal morbidity, there is an even stronger association of uric acid with the risk for small birth weight infants and with overall foetal mortality. The hyperuricemia of preeclampsia has been variably suggested to be associated with lactic acidosis, altered renal functions or oxidative stress.AIM: To Study and compare renal function tests in Pre-eclampsia and Eclampsia with normal healthy pregnant women and assess the ante-partum severity in both the diseases.
Materials and Methods: Study was conducted on 70 pregnant women admitted with pre-eclampsia and eclampsia and 35 normal pregnancy patients in between 19-26 yrs of age in third trimester of pregnancy.
Results: There is a increase in Diastolic blood pressure in mild pre-eclampsia and significant increase in severe pre-eclampsia and eclampsiapatientswhen compared to controlsThere is a increase in serum uric acid in mild pre-eclampsia and significant increase in all parameters insevere pre-eclampsia and eclampsia patientswhen compared to control.
Conclusion: There is a derangement of parameters of RFT in severe preeclampsia and eclampsia.But there was no significant elevation in mild pre-eclampsia.Persistant Renal parameter that  increased was Uric acid. These can be taken as a predictor of the disease.

The Importance Of Uric Acid Level In Patients With Persistent Kidney Disease Of Predialysis Stages

Dano A. Egamberdieva; Botir T. Daminov; Iroda A. Ruzmetova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3417-3429

The study explores theory of relativity of acid levels with nephritic function, moreover as its role as a prognostic marker of cardio tube risk in chronic excretory organ diseases within the course of variable regression analysis, taking into consideration the adjustment of potential risk issues, the amount of uric acid was found to be a major factor influencing calculable capillary vessel filtration rate. The results of this study showed that elevated humor uric acid levels are related to the next risk of kidney malfunction.

Effect Of Endovascular Revascularization On Renal Function

Botir T. Daminov; B.A. Alyvi; Shavkat K. Muminov; Lola T. Daminova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3444-3453

To research the short-term and long-term effect of coronary artery stenting on renal function. In patients with coronary heart disease within 3 months after endovascular revascularization-preserving renal dysfunction, despite the normalization of creatinine concentration.