Online ISSN: 2515-8260

Keywords : Prognosis


COUNTER CORRELATION AMIDST SERUM ZINC AND ALRI AGONY IN HOSPITALIZED PEDIATRIC SUBJECTS: A CROSS SECTIONAL STUDY

Oruganti Lalitha, G. Madhavi Prasanna, Shyamala Gowri Pocha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2031-2038

Background: One of the prime global health problem in children is pneumonia accounting for 29% of mortality worldwide. One of the important micronutrient in humans which plays vital role in stimulation and proper functioning of immune system and prevents infections is zinc. There is a strong correlation between risk of pneumonia in a population with zinc deficiency with high rates of infections such as diarrhea, skin, and respiratory infections. The prime objective of present study is to provide further experimental support to strengthen above correlation. To study the serum zinc levels in children hospitalised with pneumonia and correlation between serum zinc levels and severity of pneumonia and its complications.
Materials and Methods: This observational cross sectional study included 100 subjects (100 with pneumonia and 100 without pneumonia) aged between <12 months to 5 years of age diagnosed with various levels of pneumonia. A detailed history, clinical examination, chest X-ray findings, arterial oxygen saturation (SpO2), haemoglobin (g/dl), WBC count and serum zinc levels (µg/dl) was noted.
Results: Mean serum zinc levels in cases was significantly low compared to age and sex matched controls (p value-0.001). Low serum zinc levels were associated with increasing severity of pneumonia (Pneumonia-112.21µg/dl, severe pneumonia- 41.18µg/dl, very severe pneumonia- 28.38µg/dl). Mean serum zinc levels in complicated pneumonia and death cases was very low 22.28µg/dl compared to those with no complications 189.94µg/dl and who were discharged 197.67µg/dl. Low serum zinc levels were associated with prolonged hospital stay and prime cause of death in children.
Conclusion: Our study results conclude that there is a contrary relation between serum zinc and different stages of pneumonial agony than in matched healthy controls. Prognosis could be augmentation of zinc in hospitalized children with acute lower respiratory infection.

Evaluation of prognosis in patient’s with perforation peritonitis using Mannheim’s peritonitis index

Tushar Dani, Mohit Kumar Patel, Manish Sahu, Dipak Purohit

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1092-1099

Background: Peritonitis is one of the most common infections, and an important problem that a surgeon has to face. Objectives: To evaluate the prognosis of patients with perforation peritonitis using Mannheim Peritonitis Index. Materials and Methods: This study was conducted from cases attending our institute in which diagnosis of peritonitis is established by operative findings or surgical interventions during management.
Results: 87 patients had MPI score of less than 21,70 patients had MPI score between 21 to 29 while 43 patients the MPI score was more than 29.There was no mortality in the patient’s with MPI score of less than<21. The mortality was 4.3% in patients with MPI scores between 21-29.The mortality was 67.4 % in the patients with MPI score more than 29.
Conclusion: MPI is accurate to be used with patients with peritonitis and should be considered reliable and simple reference for estimating their risk of death.

Prospective Analysis of Burden of Hypersensitivity Pneumonitis at a Tertiary Care Hospital

Madhurmay, Rajendra Kumar Saini

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 653-656

Background: Establishing whether patients are exposed to a ‘known cause’ is a key
element in both the diagnostic assessment and the subsequent management of
hypersensitivity pneumonitis (HP).
Objective: The aim of the study is to determine the burden of hypersensitivity
pneumonitis at a respiratory center.
Methods: 100 patients had been enrolled to the study. Demographic, clinical,
radiological and aetiological data were collected with a random identification code for
each patient in view of maintaining the confidentiality during data collection.
Results: Out of 100 patients, there were 65 females and 35 males. Mean age of the
population was 55.50 years (SD = 10.50) years. 50 patients were less than 65 years of
which 30 were aged between 45 to 60 years while 20 were aged <5 years.
Conclusion: In general, patients with acute disease, if correctly and timely diagnosed
and treated, have a good prognosis, and patients usually improve. By contrast, patients
with subacute/chronic HP (in particular those with bird fancier’s disease) often
progress to irreversible pulmonary fibrosis and may die within a few years after
diagnosis.

Prognostic Significance of Tumor Infiltrating Lymphocytes in InvasiveBreast Carcinoma.

Dr.Safaa Qatleesh, Prof. Ayman Sammoun, Prof. Eyad M Chatty

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 385-392

Background:Breast cancer is a major public health problem for woman. Several
studies suggestedthat development and progression of malignant tumors are
characterized by an interaction with the cells in the tumor microenvironment
including infiltrating immune cells.
Aim:The aim was to investigate relationship between tumor infiltrating
lymphocytes(TILs) in infiltrating breast carcinomaand other recognized
clinicopathological factors.
Material and Methods: 100 cases of infiltrating breast carcinomas were included in
the study.Stromal.TILs status was evaluated using hematoxylin and eosin staining.
For all statistical data chi-square test was applied using SPSS and Spearman
correlation.P‐ values of less than 0.05 were considered as significant.
Results: Stromal TILs correlated with well-established prognostic markers:HER2
positivity(P=0.001),higher tumour grade (P=0.016), ER negativity (P=0.015), PR
negativity (P=0.008),lymphnode status(P=0.005) and lymphovascular invasion(LVI)
(P=0.001), molecular classification (P=0.000) , and p53 positivity (P=0.013). No
correlation between CD10 positivity or high proliferative index( KI67)and stromal
TILs.
Conclusion:Stromal TILs is directly correlated more aggressive phenotype:HER2
positivity ,ER negativity, PR negativity ,molecular classification, present LVI,
higher tumor grade and greater nodal involvement;so TILs could be used as novel
predictive and prognostic parameter and used to develop newer drugs
(immunotherapy).

Prognostic Significance of Tumor Infiltrating Lymphocytes in InvasiveBreast Carcinoma

Dr.Safaa Qatleesh, Prof. Ayman Sammoun, Prof. Eyad M Chatty

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 329-366

Background:Breast cancer is a major public health problem for woman. Several
studies suggestedthat development and progression of malignant tumors are
characterized by an interaction with the cells in the tumor microenvironment
including infiltrating immune cells.
Aim:The aim was to investigate relationship between tumor infiltrating
lymphocytes(TILs) in infiltrating breast carcinomaand other recognized
clinicopathological factors.
Material and Methods: 100 cases of infiltrating breast carcinomas were included in
the study.Stromal.TILs status was evaluated using hematoxylin and eosin staining.
For all statistical data chi-square test was applied using SPSS and Spearman
correlation.P‐values of less than 0.05 were considered as significant.
Results: Stromal TILs correlated with well-established prognostic markers:HER2
positivity(P=0.001),higher tumour grade (P=0.016), ER negativity (P=0.015), PR
negativity (P=0.008),lymphnode status(P=0.005) and lymphovascular invasion(LVI)
(P=0.001), molecular classification (P=0.000) , and p53 positivity (P=0.013). No
correlation between CD10 positivity or high proliferative index( KI67)and stromal
TILs.
Conclusion:Stromal TILs is directly correlated more aggressive phenotype:HER2
positivity ,ER negativity, PR negativity ,molecular classification, present LVI,
higher tumor grade and greater nodal involvement;so TILs could be used as novel
predictive and prognostic parameter and used to develop newer drugs
(immunotherapy).

PREDICTION OF THE DEVELOPMENT OF RENAL DYSFUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE

Kamilova Umida; Nuritdinov Nuriddin; Zakirova Gulnoza

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1368-1374

Purpose. To identify prognostic factors for the development of renal dysfunction (RD) and to develop a method for
assessing and predicting RD in patients with chronic heart failure (CHF).
Methods. A total of 101 patients with functional class I-III (FC) CHF (according to the classification of the New
York Heart Association) were examined. Also, the patients were divided, depending on the glomerular filtration
rate, determined by the calculation method according to the CKD-EPI formula (eGFR), into two groups: patients
with eGFR≥90 ml / min (n = 20), with eGFR <90 ml / min (n = 81). All patients were determined: creatinine (Cr),
eGFR according to the CKD-EPI formula, albumin / creatinine (Al / Cr) level (mg / mmol) in morning urine,
specific gravity in morning urine portion (SG); studied renal blood flow according to Doppler sonography at the
level of the common left and right renal arteries. To assess the significance of signs for determining and predicting
RD in CHF, we used a method based on Wald's sequential statistical analysis with the development of differential
diagnostic tables, determination of diagnostic coefficients (DC) and information content (J) of each sign in groups of
patients with CHF, depending on the level eGFR, determination of diagnostic thresholds (amount of DC).
Results. As a result of the developed differential diagnostic tables, the most informative signs were identified that
determine the unfavorable prognosis of RD in patients with CHF: creatinine above 80 μmol / l, eGFR less than 90
ml / min, Al / Cr ratio in morning urine more than 3.4 mg / mmol, urine specific gravity SG less than 1015,
resistance index (RI) at the level of the right and left renal arteries more than 0.7. The sum of DCs of these signs,
depending on the severity of symptoms, determines the risk of developing RD: a very high risk in the range from
+15 to +32, high risk - from +8 to +14, moderate risk - from +7 to +3, favorable course of CHF - from 0 to +2
points.
Conclusion. Signs of an unfavorable prognosis for the development of RD in patients with CHF were determined:
creatinine above 80 μmol / l, eGFR less than 90 ml / min, Al / Cr ratio in morning urine more than 3.4 mg / mmol, urine SG less than 1015, RI at the renal level arteries more than 0.7.

The Importance Of Uric Acid Level In Patients With Persistent Kidney Disease Of Predialysis Stages

Dano A. Egamberdieva; Botir T. Daminov; Iroda A. Ruzmetova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3417-3429

The study explores theory of relativity of acid levels with nephritic function, moreover as its role as a prognostic marker of cardio tube risk in chronic excretory organ diseases within the course of variable regression analysis, taking into consideration the adjustment of potential risk issues, the amount of uric acid was found to be a major factor influencing calculable capillary vessel filtration rate. The results of this study showed that elevated humor uric acid levels are related to the next risk of kidney malfunction.

Prognostic value of tumor budding in oral squamous cell carcinoma

Dr. Sandhya Sundar, Dr. Pratibha Ramani, Dr. Gheena S, Dr.Abilasha R

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 81-90

Tumor budding is the histological phenomenon seen as a detached, discohesive small cluster
of cells in the invasive tumor front. Tumor buds may provide a histological means for the
assessment of epithelial-mesenchymal interaction and facilitate early prediction of
prognosis.The present study aims to assess the prognostic significance of the tumor budding in
oral squamous cell carcinoma(OSCC). Detailed Histopathological scoring of the oral
squamous cell carcinoma tissue and lymph nodes including the evaluation of tumor budding
was performed by two individual observers retrospectively. The association between various
clinicopathological parameters and the budding index was analyzed using chi-square test and
fisher’s exact tests. Tumor budding was demonstrated in the invasive tumor front of all OSCC
cases. High-intensity tumor budding was seen in stage 4 cancers with tumor size of > 4cms.
Histologically, they were related to deep and extensive tumors, having an invasive front with
infiltrative cells in groups or cords, dense stromal type in association with mild inflammation
invariably. All of the cases with lymph node metastases were tumor budding positive. Thus this
study emphasizes the importance of tumor budding evaluation in regular pathology practice in
the management of OSCC cases.