Online ISSN: 2515-8260

Keywords : dexmedetomidine


European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1578-1583

Introduction: Pneumoperitoneum from Carbon di oxide insufflation will result in increase plasma levels of catecholamines and vasopressin that leads to hemodynamic disturbances. These effects are exaggerated by the steep trendelenburg position. This study was designed to evaluate the effect of Dexmedetomidine and fentanyl on hemodynamics in laparoscopic gynaeconcolgy surgeries which requires steep trendelenburg position.
Methods: After obtaining Ethical committee clearance and patients consent, prospective randomised comparative study was done on 60 ASA I and II patients who were randomly assigned to receive either dexmedetomidine or fentanyl infusion. Patients with ASA III & IV, on β blockers were excluded. Intraoperative hemodynamics, recovery and emergence was assessed. Students ‘t’ test was used
Results: The study included 60 patients undergoing laparoscopic gynaecology oncology surgeries requiring steep trendelenburg positions. Dexmedetomidine group of patients had better intra operative hemodynamics throughout and postoperative recovery when compared with Fentanyl group of patients.
Conclusion: Using Dexmedetomidine infusion in patients will have stable hemodynamics and postoperative recovery also smooth as compared to fentanyl.

Evaluation of The Efficacy of Dexmedetomidine And Dexamethasone When Used As Adjuvant To Ropivacaine In Supraclavicular Brachial Plexus Block for Upper Limb Surgeries

Dr Abhilash Dash; Dr Rabi Narayan Dhar; Dr Ramakanta Mohanty; Dr Sidharth Sraban Routray; Dr Soumyakant Mallick

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1166-1173

We have done this trialin order to correlate analgesic dexmedetomidine (DXM) &dexamethasone (DX) efficacyin form of an additive for supraclavicular brachial plexus(SCBP)‘s ropivacaine blockage for upper extremity surgery. This is trial in which, 18–65 yrs 70 ASA status type one and two individuals suffering from disease, posted for upper extremity surgery was splitrandomly within couple of categories. Class DXMgot 2 mlof normal saline containing dexmedetomidine (1mcg/kg) with 0.5%ropivacaine(30 ml) and Class DXgot 2 ml(8 mg) of dexamethasone with 0.5%ropivacaine(30 ml). SCBP block was performed under ultrasonography(USG). The primary outcome was time of 1st analgesic request and no of analgesic request in 1st 24hrs. Secondary endresult of the trial were Motor block& sensory were secondary trial end result onset & time & incidence associated with drug’sside effects. Time for request of 1st rescue analgesia was 720.50±67.87min in Class DXM and 591.83±52.25min in Class DX. Total rescue analgesia required within post -operative for 1 dayinto DXM Class is less in comparison to DX Class. The mean of onset time of motor block& sensory into Class DXM is lesser in comparison to Class DX, which is statistically important. In Class DXM mean of duration of sensory block was 656.50± 50.58min, which was significantly longer than Class DX where duration was 534.10± 62.43min. Mean of motor block duration was 611.83± 45.3min in Class DXM and 470.83± 59.40min in Class DX (p<0.001). Dexmedetomidine provided prolonged relief from suffering after utilizing it in form of an additive to SCBP portion’s ropivacaine when compared to dexamethasone