Online ISSN: 2515-8260

Keywords : hyperlipidemia


Clinical & histological profile of patients with nonalcoholic fatty liver disease

B. Pramida, Amreen Unnisa, Seema Khan, Khatija Shameem, Rida Fatima, Afroze Shameem, M Bhavani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 4013-4019

Background: The estimated prevalence of fatty liver in the general population averages around 14-25 % with rising prevalence in the presence of risk factors. Liver biopsy continues to be the ultimate and specific investigation for assessing the nature and severity of a spectrum of liver diseases. Present study was aimed to study clinical & histological profile of patients with nonalcoholic fatty liver disease.
Material and Methods: This study was retrospective and prospective, observational study, conducted in patients with increased echo texture of liver on routine ultra-sound scan, suggestive of fatty liver disease, prior to performing percutaneous liver biopsy, the proper preparation of a patient is important, with attention to a detailed knowledge of the procedure, a complete history and physical evaluation, medication use, and fresh clotting parameters.
Results: In present study, among 60 patients, 36 (60%) were females and 24(40%) were males. Majority were from the age group of 41- 50 years (36.66%), followed by 51-60 years (30 %).  Commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis. The commonest clinical sign was of hepatomegaly or palpable liver (90%), edema (35 %), abdominal distension (18.33 %), splenomegaly (16.67 %) & icterus (13.33 %). Various risk factors noted were dyslipidemia (61.67 %), diabetes mellites (58.33 %), hypertension (53.33 %), overweight (50 %), obese (46.67 %) & coronary artery disease (40 %). 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: Our findings were consistent with the earlier concept that non-alcoholic steatohepatitis was prevalent in obese females with diabetes and hyperlipidemia.

Study of prevalence of vitamin d deficiency and its association with diabetes mellitus, hypertension, hyperlipidemia and cardiovascular diseases among the doctors of Belagavi City, India

Vilas Honnakatti, Pratap Budhya, Shubham Malawadi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2820-2825

Vitamin D (Vit D) deficiency has been studied among various Indian populations with conflicting results. There is a paucity of data connecting the link between Vit D deficiency among the doctors who are particularly at risk of developing and causes of increase in insulin resistance, hypertension, inflammation, and increased cardiovascular risk. Also, the association between Vit D deficiency and diabetes mellitus, hypertension, hyperlipidemia, and cardiovascular diseases is unclear. Given these observations, we would like to study the prevalence of Vit D deficiency among the doctors of Belagavi city of India.
Materials and Method: It was a cross-sectional study. The study was conducted by the department of General Medicine, Belagavi Institute of Medical Sciences Belagavi, during the period from April 2016 to March 2017. All the doctors residing in Belagavi city were included in the present study after meeting appropriate exclusion criteria. The detailed history, risk factors, and laboratory finding was noted. The informed consent was taken from each participant before inclusion in the study.
Results: 100 doctors aged between 40 to 70 years were studied. The male-to-female ratio was 62:38. Predominantly males were in the age range of 41-50 years of age. The mean age for men was 51 years with SD 6.36 years and for women were 49 years with SD 6.07 years. Cardiovascular risk factors such as diabetes was seen in 58%, hypertension in 63%, and hyperlipidemia seen in 33%.
Conclusion: The prevalence of vitamin D deficiency observed in our study was 40%. There was a significant association between diabetes mellitus and hypertension in vitamin D deficiency compared with vit D sufficiency individuals. Vitamin d deficiency is commonly seen in all age groups, therefore, strategies such as increasing awareness, and educating the masses about adequate exposure to sunlight. The need for dietary rich in vitamin D sources and fortification of foods with Vitamin D.

STUDY OF CLINICAL, BIOCHEMICAL, HISTOLOGICAL PROFILE OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

A. Praveen Naik, Md. Masood Ahmed Shareef

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1640-1648

Background: Non-alcoholic steatohepatitis is a clinicopathological syndrome, characterized by the development of histological features comparable to those induced by excessive alcohol intake without alcohol abuse. This study is an attempt to evaluate the clinical, biochemical and histological profile of non-alcoholic steatohepatitis in this tertiary hospital in Rayalasema.
Material and Methods: Present study was single-center, prospective, observational study, conducted in patients of all ages, either gender, who are found to have increased echo texture of liver on routine ultra-sound scan.
Results: The present study was conducted on 60 patients, comprised of 36(60%) males and 24(40%) females. Majority were from the age group of 41 to 50 years there were 22 (36.66%) cases of which 12 (54.54%) were males and 10 (45.46%) were females.  The commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis and diagnosis was established due to abnormal sonographic finding and abnormal liver function tests during investigations for other causes. Hyperlipidemia (61.67%), diabetes mellitus (58.33%), obesity (46.67%) & overweight (50%) were the most commonly associated risk factors noted. 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: This study demonstrates that features suggestive of the metabolic syndrome are observed more frequently in patients with non-alcoholic steatohepatitis, share many of the systemic disorders that constitute insulin resistance syndrome, hyperlipidemia, hypertension, obesity, type 2 diabetes and hepatic steatosis.

Analysis Of The Assessment Of The Attitude To The State Of Its Health Among The Inorgonized Population

Jo‘rayeva Hafiza Iskandarovna; Soliyev Alisher Urakovich; Djumayev Karomat Shoyimovich; Khusenov Olim Nutfilloyevich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3346-3352

Analysis of the assessment of attitudes towards their health among the unorganized population. With the important role of timely and adequate detection of various diseases and pathological conditions by doctors of the health facility, the adequacy of assessing patients health is of particular importance. An adequate assessment of the patient's own health is an important help in the timely referral to the doctor and the conduct of the preventive measures. In this regard, the frequency of the main components of the metabolic syndrome among people who differ in assessing their health was analyzed.
Among the unorganized population of Bukhara there is an inadequate assessment of the state of health among patients with arterial hypertension, with body mass index and obesity and a violation of carbohydrate metabolism.