European Journal of Molecular & Clinical Medicine

Introduction: Elevated anti-thyroid peroxidase (Anti-TPO) antibodies and thyroid
stimulating hormone (TSH) levels in hypothyroidism have been linked to the alter the
vitamin B12 metabolic pathway thereby imparting the anemia. Thyroid peroxidase is
an important enzyme responsible during organification of iodide for synthesis of
thyroid hormone. Antibodies to TPO are formed as a part of autoimmune response of
body causing autoimmune thyroiditis in patients. Antibodies to thyroid peroxidase
(TPO) are clinically useful markers of thyroid autoimmunity
Objectives: Present study aims to correlate the thyroid stimulating hormone and antithyroid
peroxidase expression in Anti-TPO positive patients with the anemia.
Methods:60 patients who were anti-TPO positive and hypothyroid were recruited in
present study.TSH level, anti-TPO antibodies level and haemogram was analysed
among all patients.
Results: There was a positive correlation between the haemoglobin and TSH level (r=
0.09580). There was a negative correlation between the Haemoglobin and Anti-TPO
expression (r= -0.2086).
Conclusion: Present study revealed a correlation of anemia with TSH level and Anti-
TPO expression which have the diagnostic value. Anti-TPO positive hypothyroid
patients have risk of developing anaemia.

(CD) is a chronic inflammatory disorder of the upper small intestine caused by an inflammatory T-cell response to the ingestion or storage proteins in wheat (gliadin), rye (secalin), and barley (hordein), which are collectively called “gluten”, and possibly oat products. (ATD) is the most common autoimmune condition, an acting approximately 2% of the female population and 0.2% of the male population. Thyroiditis has been repeatedly associated with celiac disease. (TTG-A) has proved to be a very specific indicator to identify patients with CD. (anti-TPO), (anti-TG) and (anti-TSHR) is a main feature of autoimmune thyroid disease.
Methods; One hundred and sixteen submitted in this study 86 patient for CD and 30 control (healthy), tested for (TTG-IgG, TTG-IgA, Anti-TSH Anti-TPO and Anti-TG) by use ELISA method.
Results; (TTG-IgG) with (TTG-IgA, Anti-TSH) show statistical significant, (TTG-IgG) with (Anti-TPO, Anti-TG) show statistical non-significant. (TTG-IgA) with (TTG-IgG, Anti-TSH) show statistical significant. (TTG- IgA) with (Anti-TPO, Anti-TG) show statistical non-significant.
Conclusion; There are a strong association between CD and autoimmune thyroid disorders