Online ISSN: 2515-8260

Keywords : thyroid disease

Analysis Of Thyroid Profile In Type-2 Diabetes Mellitus Patients

Abdur Rahim Abidi; Ravjit Kaur Sabharwal; Niamatullah Zaheer; Pranav Kumar Prabhakard

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4383-4390

Diabetes mellitus and thyroid gland abnormalities are interlinked and coexist with influencing each other. Current study was planned and conducted to evaluate thyroid status in patients with type-2 diabetics. The main aim of the study was to understand the relationship between diabetes mellitus and thyroid abnormalities. Total 100 known diabetic patients were studied, out of them 37 were males with the mean age 59.81 ± 12.8 years, and 63 females with average age of 55.31 ±11.10 years. 50 non-diabetic healthy subjects included 13 males and 37 female of mean age 48.86 ± 12.9 and 48.86 ± 17.94 years respectively selected as a control. All the patients were evaluated for thyroid profile (TSH, FT3, and FT4) and diabetic profile (RBS and HbA1c) by using Cobas C-311 and Cobas E-411 fully automated immunoassay analyzer. The observations were recorded. The result showed that, out of 100 diabetic subjects 41.03% male and 58.97% female were faced with euthyroid and the remaining 22% had thyroid dysfunctions. Hypothyroidism was more common in females (78.97%) as compared to men (21.05%). The mean values for TSH, FT3 and FT4 at (p> 0.05%) probability level shows statistically no significant difference. The relationship between diabetes and thyroid abnormalities was significantly difference, interdependency of these two conditions and evaluation of thyroid hormones status with the diabetic profile in the early days of diabetes is recommended. This will induce the management strategies of diabetes and can delay and avoid the progression of the secondary complications in diabetic patients with uncontrolled diabetes.

Association Of Oral Lichen Planus And Thyroid Disease - A Case Control Study

Manthra Prathoshni.S; Muthukrishnan Arvind; Visalakshi Ramanathan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3137-3149

Introduction: Lichen planus, is a chronic autoimmune, mucocutaneous disease affecting the oral mucosa besides the skin, genital mucosa, scalp and nails.The exact etiology of oral lichen planus is unknown. The disease most commonly affects middle-aged females. Oral lichen planus usually presents as white striations (Wickham's striae), white papules, white plaque, atrophic , ulcerative, erosive or as blisters. There is a well established correlation between oral lichen planus and liver disease. Opinion amongst researchers vary on terminology of lichen planus and lichenoid drug reaction . Recent literature reported association between lichen planus and thyroid disease.
Aim: The main aim of this study is to evaluate the association between oral lichen planus and thyroid disease and its prevalence amongst patients visiting our dental institute.
Materials and methods: 67 case sheets of patients, diagnosed with oral lichen planus between June 2019 and March-2020 were retrieved from the electronic database . Collected data were entered into the Excel sheet and was analysed using SPSS analysis.
Results: Results showed a positive association between oral lichen planus and thyroid disease, mainly hypothyroidism (7.46%). Females were more affected than males (53.7%).The erosive variant of oral lichen planus was more prevalent among the study population (44.7%). There was a positive correlation between predominant clinical variety of Lichen planus and site involved. The positive correlation between hypothroid state and lichen planus is also reported.
Conclusion: In conclusion, our study establishes an association between oral lichen planus and a coexisting thyroid disorder mainly hypothyroidism .