Online ISSN: 2515-8260

Keywords : synthesis

Synthesis of Novel anti UV- Reactive Dyes and their applications on textile fabric

Saadia Abd Elmegied; Magda M. Kamel; Badria M. Youssef; Safia A. Mahmoud

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2070-2088

New anti UV- reactive dyes (1-4) were synthesized from its structure was confirmed by 1HNMR and IR spectroscopy and their dyeing behavior and ultraviolet (UV) protection on cotton and wool fabrics were investigated. From the study, we can see that the exhaustion value reached over 85%, the T (UVA) and T (UVB) were 3.3% and 3.4%, respectively. The fabric dyed with anti UV- reactive dyes had very good ultraviolet radiation protection. The effects of varying dyeing conditions were investigated. Fabrics dyed with anti-UV dyes were tested for color strength (K/S), rate of fading (ΔE) values. The dyed fabrics also showed very good light fastness and good to excellent washing, rubbing, and perspiration fastness. In this paper our work aiming to reduce the undesirable photodegradation effects of UVR on dyed fabrics by applying these new anti UV- reactive dyes.


Khairnar N. S.; Patil A. V.; Noolvi M. N.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5201-5214

A novel series of triazolylquinazolin-4-one derivatives have been synthesized and characterized by TLC, melting point, FT-IR, 1H NMR and mass spectroscopy data. The synthesized series of title compounds were subjected for docking studies using Schrodinger Glide software, evaluated for their potential to inhibit enzyme EGFR-tyrosine kinase followed by in-vitro anticancer activity by SRB assay method on HeLa, MCF-7, A-549 cell lines. The series of compounds shows anticancer activity probably by inhibiting the enzyme EGFR-tyrosine kinase.

Amides Of Ricinoleic, Lactic, Sorbic, Cinnamic And Itaconic Acids Based On Homoveratrylamin

Z. E. Urunbaeva; M. Alimova; A.Sh. Saidov; V.I. Vinogradova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 661-665

Amides of ricinoleic, lactic, cinnamic, sorbic, itaconic acids with homoveratrylamine have been synthesized in 70-88% yields. The structure of the obtained compounds was confirmed by the data of NMR spectroscopy and gas chromatography-mass spectrometry.

A Facile Synthesis, Structural Elucidation and Biological Evaluation of dihydropyrimidinone compound

S. Shanmugam; K. Neelakandan; M. Gopalakrishnan; S. Pazhamalai

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4038-4056

The chemical structure of the newly synthesized compound Ethyl-6-methyl-2-oxo-4-(3,4,5-trichlorophenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 4 was confirmed by elemental analysis, 1H NMR, 13C NMR, and ESI-HRMS spectral data. In addition, in the form of the complete and partial density of states, the HOMO-LUMO energy gap, and electrostatic potential map, etc., some quantum chemical insights have been obtained. Furthermore, to demonstrate the possible applications of dihydropyrimidinone 4 in nonlinear optics, the polarizability and first hyperpolarizability were measured. Molecular docking is also determined in order to illustrate the over expression of estrogen receptor in 92 % of 2J9M protein. The antitumor activity of these compound was evaluated on breast cancer (MCF-7) cell lines by a cell viability assay utilizing the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Although with varying degrees, a significant growth inhibitory and cytotoxic effect was observed on MCF-7 cancer cell line. The tested compound 4, was active against MCF-7 cell line (in-vitro analysis) with IC50 values of 45 μM. The compound was subjected for the DPPH & ABTS tests, evaluated its antioxidant activity. With further characterization, mechanism of biological action, this compound 4 shall be a potential / useful candidate as anticancer drug.

Synthesis, antimicrobial activity and Molecular docking study of some novel thiazolidine-2,4-dione derivatives

Pankaj Sharma, Chandra Shekhar Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 6075-6087

A series of novel thiazolidine-2,4-diones was synthesized and investigated for antimicrobial activity. The structures of all synthesized compounds were confirmed by means of elemental analysis, IR, 1H NMR, and LCMS. All compounds were evaluated for antimicrobial activity cup plate method against S. aureus, B. anthracis, P. aeruginosa, E. coli, C. albicans and A. niger. Compounds 2d and 2l showed significant activity against gram positive and gram negative bacteria. In case of antifungal activity, the zone of inhibition was ranging from 10 to 23 mm and the compounds 2c and 2e showed significant activity against the fungal strains as compared with fluconazole.