Online ISSN: 2515-8260

Keywords : anti-cancer

Role Of Flavonoids In Cancer Prevention: Chemistry And Mode Of Action

Harpreet Kaur; Tanu Bansal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3608-3625

Plants derived compounds have been successfully used as anti-cancer medicine so far. Paclitaxel, pomiferin, roscovitine are the few examples of plant derived drugs. There are a number of plant constituents which are being studied for their anticancer activity and still there are a number of natural products that are under various stages of clinical trial. Many researchers are working on these compounds so as to find out their mode of action and selectivity of cancer cell line. Exhaustive work is being done to get promising anti-cancer agents in future. In the present review, naturally occurring flavonoids have been considered and their role in controlling cancer is being investigated. A study of their mode of actions and categorization of their molecular targets have been done.


Sudarsan R; Lakshmi T; Anjaneyulu K

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1701-1713

A wide range of organic compounds that are naturally occurring called flavonoids are primarily found in a large variety of plants. Some of the sources include tea, wine, fruits, grains, nuts and vegetables. There are a number of studies that have proven that a strong association exists between intake of dietary flavonoid and its effects on mortality in the long run. Flavonoids at non-toxic concentrations are known to demonstrate a wide range of therapeutic biological activities in organisms. The contribution of flavonoids in prevention of cancer is an area of great interest in current research. A variety of studies, including in vitro experiments and human trials and even epidemiological investigations, provide compelling evidence which imply that flavonoids’ effects on cancer in terms of chemoprevention and chemotherapy is significant. As the current treatment methods possess a number of drawbacks, the anticancer potential demonstrated by flavonoids makes them a reliable alternative. Various studies have focussed on flavonoids’ anti-cancer potential and its possible application in the treatment of cancer as a chemopreventive agent. This article summarizes the effects of flavonoids in relation to its anticancer potential and its clinical application in treatment of oral cancer.