European Journal of Molecular & Clinical Medicine

Background and Aim: Post operative bleeding is very common post operative complication seen in extraction cases. Anti coagulant therapies are employed to manage several clinical conditions. Patients those who are already on anti coagulant therapy, can show different patterns of post extraction hemorrhage. Anti coagulant makes blood flow via veins more easily. So, blood will be less likely to make a dangerous blood clot (like thrombosis or embolism). The sole endeavor of present study was to evaluate the correlation of post extraction hemorrhage and anti coagulant therapies in younger population. This study was retrospectively performed to assess the related prevalence also in the studied population. Materials & Methods: Patients case history, follow up case sheet and discharge summaries were explored. Younger age group patients those had undergone single tooth atraumatic extraction for different reasons, were selected for study. Patients who reported to be on anticoagulant therapy for more than one year, were studied in group one. Patients who reported to be on anticoagulant therapy for six to twelve months, were segregated in group two. Patients who reported to be on anticoagulant therapy for less than six months, were studied in group three. Patients not receiving this therapy were served as control group or group four. Post operative bleeding was studied under five categories in each group. These were mild, moderate, severe, uncategorized and no bleeding. Statistical Analysis and Results: Statistical analysis was done by statistical software Statistical Package for the Social Sciences (SPSS). P ≤ 0.05 was considered as statistically significant. Total 84 male and 36 female patients were studied in this study. Therefore, majority of the studied patients were male. In group I, 9 out of 30 patients had no bleeding. However, 8 patients showed severe post operative bleeding. 5 patients showed only mild bleeding. In this group (group I), P value was significant for all five severities of bleeding. In group IV, 23 patients had no post operative bleeding. Nevertheless, only 1 patient showed severe post operative bleeding. Only 1 patient showed mild bleeding. In this group (group IV), P value was significant for patients with no post operative bleeding (0.03). Conclusion: Within the limitations of the study, authors concluded that anti coagulant therapies are significantly affecting post operative bleeding in extraction cases. The relative severity and prevalence of bleeding are also exaggerated by time period of anti coagulant therapy. Patients those who were on anti coagulant therapy for more than one year, showed maximum prevalence and severity of bleeding.

Objectives: To assess the quality of INR control in Egyptian patients who are on warfarin
therapy through calculating the TTR and study different variables affecting INR control in
those patients. Methods: A Retrospective cohort study conducted in Cardiology Department,
Zagazig University Hospitals, from December 2018 to August 2019. It included 250 patients
who were prescribed Warfarin therapy for different indications. Results: After calculating
TTR of each patient the level of anticoagulation control was determined using the
following cut off values: a) Good control: TTR>70%, b) Intermediate control: TTR 50 -70
%, c) Poor control: TTR <50%. Majority of patients 62% had poor control with TTR less
than 50% and 17.20% had Intermediate control with TTR 50-70%. Patients with good TTR
control represented 20.8%. Conclusion: Majority of Egyptian patients have poor
anticoagulation control by means of TTR. Male gender, higher education and employment
status are associated with higher mean TTR and better anticoagulation control. Male
gender and employment were significant predictors for good INR control.

Patients with Chronic Kidney Disease (CKD) develop a tendency to bleed and
thromboembolism, so the indication for anticoagulants at the attachment of atrial
fibrillation (AF) is complex. AF is the most common chronic heart arrhythmia, and
thromboembolism and ischemic stroke in particular are the main complications. In recent
years, new oral anticoagulants have been developed and they have shown superiority over
the classic antivitamin K anticoagulants in preventing the risk of stroke, systemic embolism
and bleeding, providing an effective alternative to these resources