European Journal of Molecular & Clinical Medicine

Background: The aim of the present study is to the comparison of viral load suppression and increase in CD4 count in the HIV reactive patients by the new regimen (TLE) within shorter period compared to the old regimen (TLD).
Material and Methods: The study includes newly diagnosed100 HIV patients. The data collected included age, sex, regimen used by the HIV patients, CD4 count and Viral Load count. Out of these 100 patients 50 of them were initiated on old ART regimen (TLE) and other 50 of them were initiated on new ART regimen (TLD). The CD4 count was estimated using Flowcytometry (BD FACS Count^TM) and Viral Load count was estimated by RT-PCR technique (Abbott HIV-1 Assay).
Results: After 6 months out of 50 patients who were on TLE (old regimen),40 of them showed CD4 count,>560 cells/mm³ and Viral Load target not detected and 10 of them showed CD4 count >460 cells/mm³ and Viral Load 300 copies/ml. and out of 50 patients on TLD (new regimen), 45 of them showed CD4 count, >650 cells/mm³and Viral Load target not detected and 5 of them showed CD4 count >500 cells/mm³ and Viral Load 150 copies/ml. After 12^th month out of 50 patients who were on TLE (old regimen), showed CD4 Count > 680 cells/mm³ and 45 of patients showed viral load target not detected and 10 showed 210 copies/ml. After out of 50 patients who were on TLD (new regimen) showed CD4 Count > 800 cells/mm³ and Viral load target not detected.
Conclusion: Present study concluded that, the new regimen (TLD) is well- tolerated and more efficient in viral suppression than old regimen (TLE).The immunological monitoring is essential for the overall success of treating, monitoring and control of HIV.

BACKGROUND
            Clinically significant hematologic abnormalities are common in HIV infection. Early identification of the hematologic abnormalities would lead to appropriate planning of treatment strategies and prevent further complication. This study was conducted in order to know the pattern of these hematologic abnormalities and its correlation with CD4 count among HIV patients of Vindhya region who were on ART.
METHODOLOGY
            This was a cross sectional, analytic study conducted in the Department of Medicine, SSMCRewa, M.P. between January 2020 to June 2021. The study group included a total number of 200 patients with HIV infection on ART. Patients were investigated for Hb%, total count, differential count and platelet count. CD4 count was obtained by flow cytometric analysis.
AIMS AND OBJECTIVES:
To analyse the hematological profile of people living with HIV/AIDS and To identify the possible correlation between CD4 count and hematological abnormalities.
RESULTS
            Among 200 patients,52.0%were males and 48.0% were females.90.5% were from rural area.The maximum no. of cases had heterosexual mode of transmission, i.e. 179 (89.5%).Out of 145 anemic cases, maximum no. i.e. 68 (46.89%) cases had normocytic anemia followed by 42 (28.97%) cases of macrocytic anemia.Among patients who had ≤200 CD4 counts, 21.27% cases had severe anemia whereas among patients who had >500 CD4 counts none had severe anemia.11.0%ofpatients hadthrombocytopenia. Among patients who have ≤200 CD4 counts, 23.40% have thrombocytopenia whereas among patients who had>500 CD4 counts only 4.87% had thrombocytopenia.   
CONCLUSIONS
            Hematologic manifestations of HIV infection are common and frequent with progression of disease.
            The Present Study revealed a significant increase in the number and severity of cases of anemia with decreasing CD4 cell count.
            We have to provide proper awareness and education about the HIV safety measures, especially in young adolescents and adults, emphasizing to rural population.
            It is important to simultaneously treat HIV patients for hematologic manifestations to reduce morbidity.

Background and Objectives: Scientific advances in cariology, dental products, and diagnostic
systems have altered dentistry's approach to the diagnosis and management of dental caries
over the last few decades. The review was undertaken to discuss the scientific rationale for
early diagnosis, a modified classification of caries based on the location and size of lesion
remineralization, the reduction of cariogenic bacteria, and the design, techniques, and
material selection for minimally invasive cavity preparation. Materials and Methods:
Literature survey was carried out in April 2021 in electronic databases such as PubMed,
SCOPUS, EMBASE, COCHRANRE library, Science Direct and manually using key words
such as “Minimally Invasive Dentistry,” “ART,” “MID,” “Minimum Intervention Dentistry”.
The searches revealed 911 articles out of which 34 were selected after reading the full text
articles. Conclusions and Practice Implications: Scientific advancements have led to the
development of minimally invasive dentistry. Emerging technology will aid the transition to
primary caries prevention, but there are still technological, cultural, and economic barriers to
their full adoption in clinical practice.

The object of this research is the photographic art of Uzbekistan, and the subject
of the research is the analysis of the specifics of photographic art as the essential structure
of modern culture of Uzbekistan. The purpose of the work is to identify and analyze the
specifics of the photographic art of Uzbekistan in the historical and cultural context and
the purpose of the work defines the following tasks: To outline the main modern problems
of understanding photos and ways to solve them. In this work we carried out a cultural
analysis of the development of photographic art in Uzbekistan in the XX - XXI centuries;

Art and Design is a medium of communication. It reflects the artistic talent and thought process of an individual or a group. This medium is chosen by artists, art students, or designers because they enjoy challenges in both educational and human experience articulations in the mode of communication so that art is multi phased and complicated. But the design is a customer-focused workflow that drives the development with regard to the customer's needs. It is the perfect mix of creative ideas and technology within a framework for adequate communications. This study is articulated in the time of the Pandemic (Covid-19) when all the conventional mediums of art are not feasible as a medium of interaction so that art and design are shifted on the different platforms. This research is motivated to find out the correlation between art and design and to examine their roles in the contemporary situation; they are important instruments for manipulating every heart and mind.

The emergence of craftsmanship in the conscious life of mankind is the most important historical step taken towards civilization. It is aimed at continuing the national handicraft traditions of Uzbekistan, providing full support to artisans, promoting the rich cultural heritage of the world community. Our world-famous architectural monuments, which gave impetus to the rapid development of the Uzbek national decorative art, testify to the wonderful harmony and integration of plaster, tile, painting, calligraphy, stonemasonry and other arts. Many applied decorative arts enrich the spiritual world of people, shape their artistic taste, nurture their psyche. That is why many applied arts are one of the most important sources in the universal education of people's art and morality, in the formation of their scientific views and in raising their cultural level.

The article is devoted to the phenomenon of the merging of traditional elements with the main directions and forms of the existence of traditional culture in modern conditions of ethnic culture. Folk art, which is an integral part of universal culture, has a special place in the life of every nation in the world, in the development of its way of life and values. The emergence of craftsmanship in the conscious life of mankind is the most important historical step taken towards civilization. It is aimed at continuing the national handicraft traditions of Uzbekistan, providing full support to artisans, promoting the rich cultural heritage of the world community.